Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery

Recruiting 50 enrolled B.P. Koirala Institute of Health Sciences

RandomizedParallel-groupSingle-blindTreatment

Summary

Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response. Use of corticosteroids decrease tissue mediators of inflammation and reduce edema. Use of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptides.

Timeline

Start: 2024-09-25
Primary completion: 2024-12-25
Completion: 2025-01-25

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Chymotrypsin	Protein / enzyme biologic	1 unknown	Oral
Comparator	Dexamethasone	Small molecule	8 mg	Other

Indications

No indication recorded.