drugset / Trial / NCT06731647
Non-steroidal Anti-inflammatory Drugs in Pleurodesis
Phase 2
Recruiting
358 enrolled
Centre Hospitalier Universitaire, Amiens
Centre Hospitalier VALENCIENNES · collabClinique Victor Pauchet · collabUniversity Hospital, Rouen · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use. However, there is a controversy in its use in pleurodesis surgery as it could block the process of pleurodesis in surgical pneumothorax. In addition, NSAIDs could increase the risk of pneumothorax recurrence. The investigators hypothesized that NSAIDs are safe during pleurodesis with a better pain management without increasing the risk of pneumothorax reccurence.
Timeline
- Start
- 2025-02-01
- Primary completion
- 2027-11
- Completion
- 2028-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ketoprofen | Small molecule | 100 mg | Intravenous |