Drugs / Ketoprofen
last change Jun 2026 re-read 2 minutes ago

Ketoprofen

Small molecule

Developed for
osteoarthritis, knee · osteoarthritis · musculoskeletal system disorder · tendinitis · bursitis · lymphedema · arthropathy · chronic pain syndrome
+11 more · female reproductive system disorder · major depressive disorder · migraine disorder · osteoarthritis, hip · pharyngitis · tenosynovitis of foot and ankle · tooth disorder · upper respiratory tract disorder · muscular atrophy · sciatica · urinary tract obstruction
Investigated by
IDEA AG · APR Applied Pharma Research s.a. · Akdeniz University · Sanofi · Hisamitsu Pharmaceutical Co., Inc. · ZARS Pharma Inc.
+43 more · Centre Hospitalier Universitaire, Amiens · EMS · Kocatepe University · Manisa Celal Bayar University · McMaster University · Pamukkale University · University Hospital, Clermont-Ferrand · University Hospital, Rouen · Assiut University · Boehringer Ingelheim · Centre Hospitalier VALENCIENNES · Centre Oscar Lambret · Clinique Victor Pauchet · Club anesthésie Reanimation Obstetricale · Dompé Farmaceutici S.p.A · Fondation Apicil · Handok Inc. · IRCCS Burlo Garofolo · Imprimis Pharmaceuticals, Inc. · KAZM Pharmaceuticals Inc. · Kufa University · Luis Fernando Simoneti · M.D. Anderson Cancer Center · Mae Stone Goode Foundation · NEURO-DOL (UMR 1107 INSERM / UCA) · NHS Tayside · National Institute of Mental Health (NIMH) · Oakville Trafalgar Memorial Hospital · Rennes University Hospital · SARL BOUCHARENC, Saint-Chély d'Apcher, France · Santelys Association · Stanford University · São Paulo Research Foundation · University Hospital, Angers · University Hospital, Caen · University Hospital, Lille · University Hospital, Montpellier · University of Iowa · University of Maryland · University of Michigan · University of Rochester · Université Clermont-Auvergne, France · X-pert Med GmbH

Regulatory milestones approvals, filings & regulatory actions · 3 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (2) US (FDA) ORUDIS 1987-07-31 – 1994-01-06 fda.gov
Approved US (FDA) ORUDIS 1986-01-09 fda.gov

Trials 54 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT03514810 Jan → Sep 2017 major depressive disorder Kufa University Completed No outcome recorded
Phase 1 NCT01020279 Oct 2009 → Jan 2010 musculoskeletal system disorder X-pert Med GmbH Completed No outcome recorded
Phase 1 NCT00745264 Oct 2007 → Mar 2008 IDEA AG Completed No outcome recorded
Phase 211 trials
Phase 2 NCT06912763 Aug 2025 → Mar 2031 expected head and neck cancer, lymphedema M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 2 NCT06731647 Feb 2025 → Nov 2027 expected pneumothorax Centre Hospitalier Universitaire, Amiens Recruiting No outcome recorded
Phase 2 NCT05062083 Jun 2022 → Sep 2023 multiple sclerosis National Institute of Mental Health (NIMH) Terminated No outcome recorded
Phase 2 NCT02439034 Feb 2015 → Sep 2016 cervical cancer, upper aerodigestive tract neoplasm Centre Oscar Lambret Completed No outcome recorded
Phase 2 NCT02180087 Feb 2014 → Aug 2015 University Hospital, Clermont-Ferrand Unknown No outcome recorded
Phase 2 NCT00647231 Mar → Aug 2008 osteoarthritis, knee Hisamitsu Pharmaceutical Co., Inc. Completed No outcome recorded
Phase 2 NCT00903994 Jun → Aug 2007 tendinitis APR Applied Pharma Research s.a. Completed No outcome recorded
Phase 2 NCT00265304 Jul 2005 → Jul 2007 osteoarthritis, knee IDEA AG Completed No outcome recorded
Phase 2 NCT00211549 Jun 2005 → ? osteoarthritis, knee IDEA AG Completed No outcome recorded
Phase 2 NCT00108810 Apr → Oct 2005 osteoarthritis, knee ZARS Pharma Inc. Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT03199417 May 2017 → May 2018 osteoarthritis, knee University of Michigan Terminated No outcome recorded
Phase 2/3 NCT02099006 Nov 2013 → Jun 2015 female reproductive system disorder University of Rochester Completed No outcome recorded
Phase 324 trials
Phase 3 NCT06202989 Sep 2024 → May 2026 KAZM Pharmaceuticals Inc. Completed No outcome recorded
Phase 3 NCT06381063 Mar 2024 → Mar 2027 expected Centre Hospitalier Universitaire, Amiens Recruiting No outcome recorded
Phase 3 NCT04421911 Mar → Sep 2020 osteoarthritis Handok Inc. Completed No outcome recorded
Phase 3 NCT03836807 Apr → Jul 2018 Dompé Farmaceutici S.p.A Completed No outcome recorded
Phase 3 NCT03025113 Mar 2018 → Nov 2019 musculoskeletal system disorder EMS Completed No outcome recorded
Phase 3 NCT02862977 Nov 2017 → Jun 2019 musculoskeletal system disorder EMS Completed No outcome recorded
Phase 3 NCT02905058 Oct 2016 → May 2017 Assiut University Completed No outcome recorded
Phase 3 NCT01890902 Aug 2013 → Jun 2014 Imprimis Pharmaceuticals, Inc. Withdrawn No outcome recorded
Phase 3 NCT00971581 Aug 2009 → May 2010 Sanofi Completed No outcome recorded
Phase 3 NCT00557544 Jun → Dec 2009 migraine disorder IRCCS Burlo Garofolo Withdrawn No outcome recorded
Phase 412 trials
Phase 4 NCT05761015 Dec 2023 → Apr 2028 expected chronic pain syndrome, osteoarthritis, hip, osteoarthritis, knee University Hospital, Clermont-Ferrand Recruiting No outcome recorded
Phase 4 NCT03911336 Jan 2023 tooth disorder University of Iowa Withdrawn No outcome recorded
Phase 4 NCT02619695 Jun 2015 → Jan 2016 Akdeniz University Unknown No outcome recorded
Phase 4 NCT02491736 Jun 2015 → Jan 2016 tenosynovitis of foot and ankle Akdeniz University Unknown No outcome recorded
Phase 4 NCT02730026 Jun 2015 → Dec 2016 Luis Fernando Simoneti Completed No outcome recorded
Phase 4 NCT02491879 Jun 2015 → Jan 2016 Akdeniz University Unknown No outcome recorded
Phase 4 NCT02393846 Feb → Jun 2015 Akdeniz University Completed No outcome recorded
Phase 4 NCT01882530 Jul 2013 → Jan 2016 Rennes University Hospital Terminated No outcome recorded
Phase 4 NCT01566253 Mar → Dec 2012 University Hospital, Montpellier Completed No outcome recorded
Phase 4 NCT02257970 Mar 2009 → Dec 2016 lymphedema Stanford University Completed No outcome recorded
Phase not applicable2 trials
NCT00530387 Jul 2008 → Jul 2011 photoallergic dermatitis NHS Tayside Completed No outcome recorded
NCT00188071 Sep 2002 → Aug 2003 University Hospital, Angers Completed No outcome recorded
Also used as a comparator or background therapy in 41 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT07319728 Comparator May 2025 → Jan 2026 overdue osteoarthritis, knee New Valley University Active not recruiting No outcome recorded
Phase 1 NCT04802967 Comparator Feb 2021 → Mar 2022 Dompé Farmaceutici S.p.A Completed No outcome recorded
Phase 1 NCT02156596 Comparator Feb 2013 → Dec 2017 urinary tract obstruction University of Monastir Completed No outcome recorded
Phase 21 trial
Phase 2 NCT00745771 Comparator Oct 2007 → Feb 2008 IDEA AG Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT02538224 Comparator Jul 2013 → Feb 2014 chronic periodontitis Islamic Azad University, Sanandaj Completed No outcome recorded
Phase 314 trials
Phase 3 NCT07108582 Comparator Apr 2026 → Jul 2028 expected chronic pain syndrome University Hospital, Strasbourg, France Not yet recruiting No outcome recorded
Phase 3 NCT04726592 Background Jul 2021 → Apr 2024 migraine with aura, migraine without aura Assistance Publique - Hôpitaux de Paris Terminated No outcome recorded
Phase 3 NCT04622813 Background Apr 2021 → Oct 2022 gallbladder disorder, neuropathy, painful, substance-related disorder American University of Beirut Medical Center Completed No outcome recorded
Phase 3 NCT03585374 Comparator Feb 2018 → Feb 2019 Mundipharma Pharmaceuticals srl Completed No outcome recorded
Phase 3 NCT02905045 Comparator Oct 2016 → Jul 2017 Assiut University Completed No outcome recorded
Phase 412 trials
Phase 4 NCT07610265 Comparator Apr 2024 → Oct 2025 Nims University Rajasthan Completed No outcome recorded
Phase 4 NCT07315698 Comparator Nov 2020 → May 2023 Indonesia University Completed No outcome recorded
Phase 4 NCT03404908 Background Feb 2018 → Jan 2019 Medical University of Lublin Completed No outcome recorded
Phase 4 NCT03244540 Background Sep 2017 → Oct 2018 neuropathy, painful Medical University of Lublin Completed No outcome recorded
Phase 4 NCT02804126 Background Jun 2017 → Jul 2018 neuropathy, painful Michał Borys Completed No outcome recorded
Phase not applicable10 trials
NCT07059429 Comparator Jul → Dec 2025 State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia Completed No outcome recorded
NCT05840406 Background Sep 2024 → Mar 2025 University Hospital Sestre Milosrdnice Completed No outcome recorded
NCT07207304 Comparator Feb 2022 → Mar 2023 hepatocellular carcinoma Iuliu Hatieganu University of Medicine and Pharmacy Completed No outcome recorded
NCT04500470 Background Sep 2020 → Jul 2021 female infertility Aswan University Hospital Completed No outcome recorded
NCT05223946 Background Sep 2020 → May 2021 Kyrgyz State Medical Academy Completed No outcome recorded

Evidence & citations 57 cited values

Every value below carries the sentence it was read from. 98 sources stand behind the page.

FieldValueCited text
Known as ketoprofen “Thirty minutes before the end of surgery, nefopam 40 mg, paracetamol 1 g, and ketoprofen 100 mg will be administered intravenously, depending on the patient's comorbidities,...” NCT07207304
90

“Standard analgesia includes ketoprofen 100 mg twice daily and paracetamol 1000 mg every 8 hours for 24 hours after knee arthroplasty; morphine 10 mg IM as needed for rescue therapy.” NCT07059429

“Intraoperative administration intravenous of dipyrone 30-50 mg/Kg and or intravenous ketoprofen 100 mg or diclofenac 75 mg or ketorolac 30 mg” NCT01734954

“Multiprofen-CC™ is a multimodal topical cream including ingredients ketoprofen (10%), baclofen (5%), amitriptyline (2%), and lidocaine (5%).” NCT06202989

“Experimental - A multimodal topical cream treatment with Ketoprofen, Baclofen, Amitryptiline, and lidocaine in a carrier gel.” NCT03199417

ketoprofen, tolperisone, symptomatic slow-acting drugs in osteoarthritis - SYSADOA - (glucosamine + chondroitin sulfate )” NCT05223946

“Each patient received one sachet that contained KLS 40 mg (equivalent to 25 mg of ketoprofen).” NCT03836807

“Both groups received intravenous analgesia with ketoprofen 100 mg regimen” NCT02239497

“2.5% ketoprofen gel (Fastjel) has been administer as 2 gr in 5 cm area.” NCT02619695

“Paracetamol 1 gram and ketoprofen 100 mg every 8 hours for 24 hours.” NCT04172272

“100 mg of ketoprofen in 50 ml volume given in 30 minutes by IV root” NCT02156596

“100 mg ketoprofen LP orally administered 30 minutes before surgery” NCT07108582

“cardiovascular risk only: ketoprofen, 50-100 mg per intake” NCT05761015

“100 mg ketoprofen intravenously every 12 hours” NCT02840526

“an NSAID (i.e. Ketoprofen ER 50 mg) at 8 AM” NCT03911336

“Treatment with Ketoprofen Topical Patch” NCT00647231

“100 mg Ketoprofen to 2 joints” NCT00745264

“200 mg KetoprofenNCT00745771

Ketoprofen 1%” NCT00530387

NCT00927641

NCT01890902

NCT00188071

NCT00317733

NCT04802967

NCT06381063

NCT00799838

NCT02178293

NCT00810121

NCT01228552

NCT04726592

NCT02568644

NCT00108810

NCT02400047

NCT03244540

NCT03585374

NCT06912763

NCT04622813

NCT07319728

NCT01211795

NCT02638831

NCT02180087

NCT00265304

NCT00903994

NCT01566253

NCT03514810

NCT01685658

NCT00488267

NCT00351104

NCT01223053

NCT02804126

NCT02439034

NCT02538224

NCT04148846

NCT03404908

NCT00792727

NCT02730026

NCT07315698

NCT01882530

NCT02248493

NCT07610265

NCT00680784

NCT00680472

NCT02862977

NCT02099006

NCT02393846

NCT05062083

NCT06731647

NCT03025113

NCT04421911

NCT05840406

NCT02905045

NCT02905058

NCT00532038

NCT00557544

NCT00365586

NCT00722852

NCT00679146

NCT02238340

NCT00971581

NCT01816334

NCT02257970

NCT01020279

NCT00426985

NCT04500470

NCT00352625

NCT00553605

NCT02491879

NCT00765700

NCT00716547

NCT00929877

NCT02491736

Known as (rs)-ketoprofen ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as 19583RP ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Actron ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Actron ketoprofen ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Alrheumat ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Aneol ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Artrosilene ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Axorid ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Capisten ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Diractin “Epicutaneously Applied Diractin® (Ketoprofen in Transfersome® Gel)” NCT00716547
2

“Epicutaneously Applied Diractin® (Ketoprofen in Transfersome® Gel)” NCT00722852

“100 mg ketoprofen from Diractin®” NCT00745264

Known as Fastjel “2.5% ketoprofen gel (Fastjel) has been administer as 2 gr in 5 cm area.” NCT02619695
Known as Fenoket 200 ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as HKT-500 HKT-500 Ketoprofen Topical Patch” NCT00680784
Known as Hydratropic acid, m-benzoyl- ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as IDEA-033 “A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free...” PMID 23542612 Mar 2013
5

“Patients treated with IDEA-033 in Study 17-007 will receive 100 mg per knee of ketoprofen gel twice daily and one placebo capsule twice daily for 52 weeks.” NCT00265304

“100 mg ketoprofen in 4.4 g transfersome gel (IDEA-033) or 4.4 g ketoprofen-free vehicle (TDT 064) topically, twice daily, for 12 weeks.” PMID 23996292 Sep 2013

NCT00211549

NCT00372333

NCT00316784

Known as Iso-k ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Jomethid xl ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Ketocid 200 ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Ketonal ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Ketoprofen l-lysinate ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as KETOPROFEN LYSINE ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Ketoprofen Lysine Salt Ketoprofen Lysine Salt Combined with Gabapentin (KLS-GABA) Compared to Ketoprofen Lysine Salt (KLS) Alone in Healthy Male Subjects” NCT04802967
Known as KETOPROFEN SODIUM ChEMBL registry synonym — accepted as the source's own label CHEMBL571
Known as Ketoprofen Topical Patch “A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Phase III Study of the Efficacy, Tolerability and Safety of Ketoprofen Topical Patch, 20% (KTP) in the Treatment...” NCT00426985