Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty
Summary
Total knee arthroplasty is a surgical treatment which involves replacing the damaged articular cartilage of the knee joint with an artificial prosthetic in end-stage knee osteoarthritis. Although total knee arthroplasties are mostly successful, approximately 1 in 5 patients are unsatisfied with their outcomes with 16-33% of patients of patients experiencing lasting pain following total knee arthroplasty. Multiprofen-CC™ is a compounded topical analgesic currently available to healthcare professionals for prescription in patients experiencing localized musculoskeletal pain. To date there has been no evidence-based guidance generated to evaluate the efficacy of Multiprofen-CC™ in osteoarthritis patients. This study will test, in patients with end-stage knee osteoarthritis undergoing total knee arthroplasty, if the use of topical Multiprofen-CC™ in addition to standard of care pain management is more effective in controlling knee pain and reducing opioid use compared to placebo plus standard care alone.
Timeline
- Start
- 2024-09-09
- Primary completion
- 2026-05-05
- Completion
- 2026-06-19
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amitriptyline | Small molecule | 2 % | Topical |
| Subject | Baclofen | Small molecule | 5 % | Topical |
| Subject | Ketoprofen | Small molecule | 10 % | Topical |
| Subject | Lidocaine | Other / unclassified | 5 % | Topical |
Indications
No indication recorded.