Non-steroidal Anti-inflammatory in Cardiac Surgery

Phase 3 Recruiting 238 enrolled Centre Hospitalier Universitaire, Amiens University Hospital, Caen · collab University Hospital, Lille · collab University Hospital, Rouen · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.

Timeline

Start: 2024-03-27
Primary completion: 2027-03
Completion: 2027-07

Publications

Huette P, Moussa M, Diouf M, Lefebvre T, Bayart G, Guilbart M, Viart C, Haye G, Bar S, Caus T, Soriot-Thomas S, Boddaert S, Alshatri HY, Tarpin P, Fumery O, Beyls C, Dupont H, Mahjoub Y, Besnier E, Abou-Arab O. Effect of non-steroidal anti-inflammatory drugs on the management of postoperative pain after cardiac surgery: a multicenter, randomized, controlled, double-blind trial (KETOPAIN Study). Trials. 2024 Sep 16;25(1):613. doi: 10.1186/s13063-024-08326-z.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketoprofen	Small molecule	100 mg	Intravenous
Background	Acetaminophen	Small molecule	1 g	—
Background	Dexamethasone	Small molecule	8 mg	Intravenous
Background	Ketamine	Small molecule	0.5 mg/kg	Intravenous
Background	Morphine	Other / unclassified	—	—
Background	Nefopam	Small molecule	20 unknown	—
Background	Oxycodone	Other / unclassified	—	—

Indications

No indication recorded.