Non-opioid Analgesic Combination With Morphine for Postoperative Analgesia.

Phase 4 Terminated 223 enrolled Rennes University Hospital

RandomizedFactorialQuadruple-blindTreatment

Summary

The combination of different analgesic drugs and/or analgesia techniques is part of the standard management of postoperative analgesia. The analysis of the literature reveals a lack of comparison of the associations of non-opioid analgesic (NOA) with morphine for postoperative analgesia. The objectives of this study are : * comparing the morphine sparing effect of different combination of 3 NOA (paracetamol, nefopam, ketoprofen) for postoperative analgesia. * determining whether the morphine-sparing effect is associated with or without a reduction in the incidence of morphine side effects. * evaluating the effects of NOA on postoperative hyperalgesia.

Timeline

Start: 2013-07-23
Primary completion: 2016-01-16
Completion: 2016-01-16

Outcome

Outcome not reported

Stopped: “Practice on postoperative pain management changed”

Publications

Beloeil H, Albaladejo P, Sion A, Durand M, Martinez V, Lasocki S, Futier E, Verzili D, Minville V, Fessenmeyer C, Belbachir A, Aubrun F, Renault A, Bellissant E; OCTOPUS group. Multicentre, prospective, double-blind, randomised controlled clinical trial comparing different non-opioid analgesic combinations with morphine for postoperative analgesia: the OCTOPUS study. Br J Anaesth. 2019 Jun;122(6):e98-e106. doi: 10.1016/j.bja.2018.10.058. Epub 2018 Dec 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acetaminophen	Small molecule	—	Intravenous
Subject	Ketoprofen	Small molecule	—	Intravenous
Subject	Nefopam	Small molecule	—	Intravenous
Background	Morphine	Other / unclassified	—	Intravenous

Indications

No indication recorded.