Comparative Evaluation of Transdermal and Oral Drugs for Management of Post-Endodontic Pain
Summary
This clinical trial evaluated whether two drugs delivered through transdermal drug delivery systems reduced post-endodontic pain as effectively as two orally administered medications in adult patients undergoing root canal treatment. The study also compared how effectively these medications controlled pain during the first 48 hours after treatment. The study aimed to answer the following questions: Did transdermal drug delivery systems provide pain relief comparable to or better than orally administered medications after endodontic treatment? Did pain intensity differ among the four treatment groups as measured using the Visual Analog Scale (VAS)? The investigators compared two transdermal drug groups with two oral drug groups to identify the treatment that provided better control of post-endodontic pain. Participants: Underwent root canal treatment for symptomatic irreversible pulpitis. Received one of four analgesic interventions consisting of two transdermal patches or two oral medications. Recorded pain intensity using the Visual Analog Scale (VAS) at 6, 12, 24, and 48 hours after treatment.
Timeline
- Start
- 2024-04-18
- Primary completion
- 2025-10-18
- Completion
- 2025-10-18
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Diclofenac | Other / unclassified | 50 mg | Oral |
| Comparator | Fentanyl | Other / unclassified | 25 ug | Other |
| Comparator | Ibuprofen | Small molecule | 400 mg | Oral |
| Comparator | Ketoprofen | Small molecule | 30 mg | Other |
Indications
No indication recorded.