drugset / Trial / NCT06912763
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
RandomizedSingle-groupDouble-blindSupportive care
Summary
To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer. Researchers will compare these drugs to find the most effective therapy for preventing or limiting these side effects.
Timeline
- Start
- 2025-08-08
- Primary completion
- 2031-03-01
- Completion
- 2033-03-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ketoprofen | Small molecule | 75 mg | Oral |
| Subject | Pentoxifylline | Small molecule | 400 mg | Oral |
| Subject | Pirfenidoneone | Unknown | 801 mg | Oral |
| Subject | Pravastatin (drug) | Unknown | 40 mg | Oral |
| Subject | Vitamin E | Other / unclassified | 1000 iu | Oral |