drugset / Trial / NCT06736691
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
Phase 3
Enrolling by invitation
315 enrolled
Swiss Tropical & Public Health Institute
Bayer · collabPublic Health Laboratory Ivo de Carneri · collabSilicon Valley Community Foundation · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and/or A. lumbricoides.
Timeline
- Start
- 2025-11-25
- Primary completion
- 2026-07
- Completion
- 2026-10
Publications
- Background Taylor L, Ahmada AA, Ali MS, Ali SM, Hattendorf J, Mohammed IS, Keiser J. Efficacy and safety of emodepside compared with albendazole in adolescents and adults with hookworm infection in Pemba Island, Tanzania: a double-blind, superiority, phase 2b, randomised controlled trial. Lancet. 2024 Aug 17;404(10453):683-691. doi: 10.1016/S0140-6736(24)01403-X.
- Background Mrimi EC, Welsche S, Ali SM, Hattendorf J, Keiser J. Emodepside for Trichuris trichiura and Hookworm Infection. N Engl J Med. 2023 May 18;388(20):1863-1875. doi: 10.1056/NEJMoa2212825.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Emodepside | Small molecule | 15 mg | Oral |
| Comparator | Mebendazole | Small molecule | 100 mg | Oral |