Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy

NCT06761989 ↗

Recruiting 104 enrolled Seoul National University Hospital

RandomizedParallel-groupOpen-labelSupportive care

Summary

This is a prospective randomized open-label noninferiority trial that compares intrathecal morphine injection and continuous wound infiltration after open pancreaticoduodenectomy.

Timeline

Start: 2025-01-15
Primary completion: 2026-12-31
Completion: 2027-01-07

Publications

Yoon S, Kim T, Lee HJ, Park N, Jung HS, Cho YJ, Kwon W, Park JS, Jung CW, Jang JY. A randomized, noninferiority clinical trial of Single-Shot Intrathecal Morphine versus Continuous Wound Infiltration for postoperative pain control after open pancreatoduodenectomy. Br J Surg. 2026 Jul 6:znag088. doi: 10.1093/bjs/znag088. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Morphine	Other / unclassified	0.2 mg	Intrathecal

Indications

No indication recorded.