drugset / Trial / NCT06778811

Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery

NCT06778811

Phase 4 Recruiting 180 enrolled Nanjing First Hospital, Nanjing Medical University
RandomizedParallel-groupTriple-blindPrevention

Summary

The aim of this clinical trial is to understand the effects of dexmedetomidine and esketamine on postoperative sleep in patients undergoing cardiac surgery. The main questions it aims to answer are: Does dexmedetomidine or esketamine prevent the development of postoperative sleep disturbances? Which one works better? The researchers compared dexmedetomidine and esketamine with saline (a drug-free solvent) to see if dexmedetomidine and esketamine prevented the development of postoperative sleep disturbances. Participants will: 1. Intraoperative continuous infusion of dexmedetomidine, esketamine or saline until the end of surgery 2. Postoperative sleep was assessed on the first and third postoperative days using a sleep rating scale

Timeline

Start
2024-10-11
Primary completion
2025-09
Completion
2025-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Dexmedetomidine Other / unclassified 0.3 ug/kg
Subject Esketamine Other / unclassified 0.3 mg/kg

Indications