drugset / Trial / NCT06800248
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
Phase 3
Not yet recruiting
315 enrolled
Swiss Tropical & Public Health Institute
Bayer · collabSilicon Valley Community Foundation · collabUniversity of the Philippines · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and/or A. lumbricoides.
Timeline
- Start
- 2026-09
- Primary completion
- 2027-04
- Completion
- 2027-08
Publications
- Background Mrimi EC, Welsche S, Ali SM, Hattendorf J, Keiser J. Emodepside for Trichuris trichiura and Hookworm Infection. N Engl J Med. 2023 May 18;388(20):1863-1875. doi: 10.1056/NEJMoa2212825.
- Background Taylor L, Ahmada AA, Ali MS, Ali SM, Hattendorf J, Mohammed IS, Keiser J. Efficacy and safety of emodepside compared with albendazole in adolescents and adults with hookworm infection in Pemba Island, Tanzania: a double-blind, superiority, phase 2b, randomised controlled trial. Lancet. 2024 Aug 17;404(10453):683-691. doi: 10.1016/S0140-6736(24)01403-X.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Emodepside | Small molecule | 15 mg | Oral |
| Comparator | Mebendazole | Small molecule | 100 mg | Oral |