Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study

Not yet recruiting 160 enrolled Second Hospital of Shanxi Medical University

RandomizedParallel-groupDouble-blindTreatment

Summary

1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3. To investigate the relationship between different doses of opioids and BMP-6 and perioperative cardiovascular adverse events in patients with lower extremity fracture surgery.

Timeline

Start: 2025-02-05
Primary completion: 2025-05-10
Completion: 2025-05-10

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sufentanil	Other / unclassified	—	—

Indications

No indication recorded.