Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use

Phase 4 Recruiting 100 enrolled University of Alabama at Birmingham National Institute on Drug Abuse (NIDA) · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

This randomized clinical trial (RCT) evaluates whether metformin can reduce systemic inflammation and improve immune function in individuals with a history of injection drug use, with or without HIV. Participants will receive metformin or placebo and undergo immune system assessments, including vaccine response evaluations.

Timeline

Start: 2025-04-07
Primary completion: 2028-11-30
Completion: 2029-11-30

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Capvaxvie	Vaccine	—	—
Subject	IMVAMUNE	Vaccine	—	—
Subject	Metformin	Small molecule	1000 mg	—

Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use

Summary

Timeline

Drugs

Indications