Effect of Nanohydroxyapatite Paste After Different Pretreatment Techniques on White Spot White Spot Lesions

Completed 40 enrolled National Research Centre, Egypt

RandomizedParallel-groupTriple-blindTreatment

Summary

forty teeth diagnosed with white spot lesions in children aged between 10-14 years old were selected to compare between the effect of using nanohydroxyapatite paste applicatio either alone or preceded by the application of HCl (hydrochloric acid) or microabrasion

Timeline

Start: 2024-12-05
Primary completion: 2025-01-20
Completion: 2025-01-30

Publications

Background Jayarajan J, Janardhanam P, Jayakumar P; Deepika. Efficacy of CPP-ACP and CPP-ACPF on enamel remineralization - an in vitro study using scanning electron microscope and DIAGNOdent. Indian J Dent Res. 2011 Jan-Feb;22(1):77-82. doi: 10.4103/0970-9290.80001.
Background Abou Neel EA, Aljabo A, Strange A, Ibrahim S, Coathup M, Young AM, Bozec L, Mudera V. Demineralization-remineralization dynamics in teeth and bone. Int J Nanomedicine. 2016 Sep 19;11:4743-4763. doi: 10.2147/IJN.S107624. eCollection 2016.
El Mansy MM, Saleh RS, Rashed MF, El-Motayam AK. Effect of nanohydroxyapatite paste after different pretreatment techniques on remineralization and color change of white spot lesions in children: a randomized control study. BMC Oral Health. 2026 Jan 13;26(1):102. doi: 10.1186/s12903-025-07365-5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	HCl	Unknown	2 %	Topical
Subject	Poly(Amidoamine) dendrimer	Small molecule	—	Topical

Indications

No indication recorded.