drugset
drugset / Trial / NCT06853431

Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia

NCT06853431 ↗

Phase 4 Recruiting 80 enrolled Second Affiliated Hospital of Wenzhou Medical University
RandomizedSequentialQuadruple-blindTreatment

Summary

For pediatric patients undergoing general anesthesia, poor anesthesia induction compliance often has adverse effects on individual behavior in the early postoperative period. Dexmedetomidine can reduce the cardiovascular responses and postoperative mental adverse reactions caused by esketamine anesthesia induction \[6\]. This study aims to explore the ED50 and ED95 and clinical effects of the combination of dexmedetomidine and esketamine nasal drops for preoperative sedation in children of different ages undergoing general anesthesia, providing a theoretical basis for the combined use of dexmedetomidine and esketamine for preoperative sedation in children undergoing general anesthesia.

Timeline

Start
2025-03-01
Primary completion
2025-11-30
Completion
2025-11-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Dexmedetomidine Other / unclassified 0.25 ug/kg Intranasal
Subject Dexmedetomidine Other / unclassified 1 ug/kg Intranasal
Subject Esketamine Other / unclassified 0.5 mg/kg Intranasal

Indications

No indication recorded.