drugset / Trial / NCT06860529
Serplulimab Combined With Chemotherapy for Early-stage HR+/HER2- Breast Cancer
RandomizedParallel-groupOpen-labelTreatment
Summary
The neoadjuvant treatment options commonly used for HR+/HER2- breast cancer are mainly anthracycline sequential or combined with paclitaxel chemotherapy regimens. Several clinical studies have confirmed that albumin paclitaxel is more effective than solvent-based paclitaxel, and therefore, albumin paclitaxel in combination with epirubicin has also become a commonly used chemotherapy regimen in clinical practice. The aim of this study was to explore the efficacy and safety of the Serplulimab combined with nab-paclitaxel and epirubicin in the neoadjuvant treatment of HR+/HER2- breast cancer
Timeline
- Start
- 2025-04-15
- Primary completion
- 2028-03-31
- Completion
- 2030-03-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Serplulimab | Monoclonal antibody | — | Intravenous |
| Background | Epirubicin | Small molecule | — | Intravenous |
| Background | Paclitaxel | Small molecule | — | Intravenous |