drugset / Trial / NCT06860529

Serplulimab Combined With Chemotherapy for Early-stage HR+/HER2- Breast Cancer

NCT06860529

Phase 2 Recruiting 357 enrolled Henan Cancer Hospital
RandomizedParallel-groupOpen-labelTreatment

Summary

The neoadjuvant treatment options commonly used for HR+/HER2- breast cancer are mainly anthracycline sequential or combined with paclitaxel chemotherapy regimens. Several clinical studies have confirmed that albumin paclitaxel is more effective than solvent-based paclitaxel, and therefore, albumin paclitaxel in combination with epirubicin has also become a commonly used chemotherapy regimen in clinical practice. The aim of this study was to explore the efficacy and safety of the Serplulimab combined with nab-paclitaxel and epirubicin in the neoadjuvant treatment of HR+/HER2- breast cancer

Timeline

Start
2025-04-15
Primary completion
2028-03-31
Completion
2030-03-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Serplulimab Monoclonal antibody Intravenous
Background Epirubicin Small molecule Intravenous
Background Paclitaxel Small molecule Intravenous