drugset / Trial / NCT06942390
Topical Metformin Versus Topical Ketotifen in Melasma Treatment
RandomizedParallel-groupOpen-labelTreatment
Summary
The study aims to evaluate and compare the efficacy and safety of a new formulation of topical metformin (nanoparticles) versus topical ketotifen (nanoparticles), both alone and combined with micro-needling, for the treatment of melasma. It is a double-blinded, randomized, split-face controlled clinical study involving 102 female patients diagnosed with bilateral melasma.
Timeline
- Start
- 2025-06-01
- Primary completion
- 2026-06-30
- Completion
- 2026-10-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ketotifen | Small molecule | — | Topical |
| Subject | Metformin | Small molecule | — | — |