drugset / Trial / NCT06972056
Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
Phase 4
Recruiting
1335 enrolled
Mayo Clinic
AbbVie · collabPatient-Centered Outcomes Research Institute · collabUniversity of Iowa · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits.
Timeline
- Start
- 2025-07-09
- Primary completion
- 2029-03-01
- Completion
- 2029-12-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Atogepant | Small molecule | 60 mg | — |
| Comparator | Propranolol | Small molecule | 160 mg | — |
| Comparator | Topiramate | Small molecule | 100 mg | — |