drugset / Trial / NCT07025824
Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation
RandomizedParallel-groupOpen-labelTreatment
Summary
The aim of this study is to compare the effectiveness and tolerability of two conditioning chemotherapies prior to allogeneic stem cell transplantation. The following will also be investigated: * Survival * Remission and Relapse rate * Engraftment or graft failure * Graft versus Host Disease (GvHD)
Timeline
- Start
- 2025-09
- Primary completion
- 2028-12
- Completion
- 2028-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Melphalan | Small molecule | 140 mg/m2 | Intravenous |
| Subject | Treosulfan | Small molecule | 2 mg/m2 | Intravenous |
| Subject | Treosulfan | Small molecule | 10 g | Intravenous |
| Background | Fludarabine | Small molecule | 30 mg/m2 | Intravenous |