Drugs / Treosulfan
Treosulfan
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | GRAFAPEX | — | 2025-01-21 | fda.gov ↗ |
| Approved | EU (EMA) | Trecondi | — | 2019-06-20 | europa.eu ↗ |
Trials 38 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 9 trials
Evidence & citations 20 cited values
Every value below carries the sentence it was read from. 51 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Treosulfan | “Venetoclax (Venclyxto®): 400 mg abs./d day -8 to -2, Fludarabine 30 mg/m2 BSA day -6 to day -2, Treosulfan 10 g/m2 BSA day -4 to day -2” NCT07214064 ↗46“followed by high dose chemotherapy with treosulfan, etoposide and cisplatin (TEC)” NCT00384553 ↗ “Conditioning with treosulfan 14 g/m2 day -6 to -4” NCT01582048 ↗ “* Vecanoid Condition * treosulfan * fludarabine” NCT04000698 ↗ |
| Known as | dihydroxybusulfan | “Treosulfan (L-threitol-1,4-bis-methanesulfonate; dihydroxybusulfan) was initially used in the treatment of certain solid tumors.” PMID 21478921 ↗ Apr 2011 |
| Known as | Grafapex | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Known as | Graftrevo | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Known as | Kepcondi | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Known as | L-threitol 1,4-dimethanesulfonate | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Known as | L-threitol-1,4-bis-methanesulfonate | “Treosulfan (L-threitol-1,4-bis-methanesulfonate; dihydroxybusulfan) was initially used in the treatment of certain solid tumors.” PMID 21478921 ↗ Apr 2011 |
| Known as | L-threitol-1,4-bis-methanesulphonate | “Treosulfan (L-threitol-1,4-bis-methanesulphonate; Ovastat(R)) is a bifunctional alkylating drug indicated for the treatment of advanced ovarian carcinoma.” PMID 12651206 ↗ Apr 2003 |
| Known as | NSC-39069 | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Known as | Ovastat | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Known as | Ovastat(R) | “Treosulfan (L-threitol-1,4-bis-methanesulphonate; Ovastat(R)) is a bifunctional alkylating drug indicated for the treatment of advanced ovarian carcinoma.” PMID 12651206 ↗ Apr 2003 |
| Known as | Threosulphan | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Known as | Trecondi | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Known as | Trecondi Ideogen | “The present study aims to combine high-dose melphalan (Melphalan Ideogen) with treosulfan (Trecondi® Ideogen), a well established bifunctional alkylating agent.” NCT05636787 ↗ |
| Known as | Trecondyv | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Known as | TREO | “Although the use of treosulfan (TREO) in conventional donor hematopoietic cell transplantation (HCT) has been extensively evaluated, its use in cord blood transplantation (CBT)...” PMID 32706891 ↗ Jul 2020 |
| Known as | Treograft | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Known as | Treosulfano | ChEMBL registry synonym — accepted as the source's own label CHEMBL455186 ↗ |
| Modality | Small molecule | “Treosulfan (powder for solution for infusion) is a marketed alkylating medication” NCT07598110 ↗ |
| Route | Oral | “Treosulfan 600 mg/m² p.o. on daý 1-28, 57-84, etc” NCT00170690 ↗ |