drugset / Trial / NCT07031765
Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade Glioma
Phase 1
Active not recruiting
12 enrolled
University of Florida
Florida Department of Health · collab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
This is a Phase I study of ex vivo expanded CD34+ hematopoietic stem cells (exHSCs) plus nivolumab in pediatric patients with histologically confirmed diagnosis of a non-brainstem high-grade glioma (NB-HGG, WHO Grade III or IV astrocytoma, oligodendrogliomas, oligoastrocytomas, ependymomas) that is recurrent, progressive or refractory following radiotherapy with or without chemotherapy. Patients must be candidates for standard of care surgical resection or biopsy.
Timeline
- Start
- 2025-07-25
- Primary completion
- 2030-12
- Completion
- 2032-12