drugset / Trial / NCT07065630
Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer
Non-randomizedSequentialOpen-labelTreatment
Summary
The purpose of this study is to assess the objective response rate following neoadjuvant therapy with volrustomig, paclitaxel, and carboplatin in previously untreated human papillomavirus (HPV)-negative locally advanced head and neck squamous cell carcinoma .
Timeline
- Start
- 2025-10-07
- Primary completion
- 2029-08-13
- Completion
- 2029-08-13
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Carboplatin | Small molecule | 5 unknown | Intravenous |
| Subject | Paclitaxel | Small molecule | 100 mg/m2 | Intravenous |
| Subject | Volrustomig | Monoclonal antibody | 250 mg | Intravenous |