Effect of HRS-8427 for Injection on the Pharmacokinetics of Furosemide and Metformin in Healthy Subjects。

Phase 1 Completed 24 enrolled Jiangsu HengRui Medicine Co., Ltd.

Non-randomizedParallel-groupOpen-labelTreatment

Summary

The pharmacokinetics of HRS-8427 for injection on the transporter OAT1 substrate furosemide and the MATE1/METE2-K substrate metformin were evaluated in healthy subjects. The safety of HRS-8427 for injection was evaluated in combination with furosemide and metformin.

Timeline

Start: 2025-07-15
Primary completion: 2025-08-15
Completion: 2025-08-15

Publications

Yin T, Qu B, Zhang Q, Xu S, Wu Y, Jiang H, Huang Y, Hu W. Pharmacokinetics, safety, and tolerability of HRS-8427, a novel anti-carbapenem-resistant cephalosporin, in healthy subjects. Antimicrob Agents Chemother. 2026 Apr;70(4):e0069425. doi: 10.1128/aac.00694-25. Epub 2026 Mar 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Furosemide	Other / unclassified	—	—
Subject	HRS-8427	Small molecule	—	Intravenous
Subject	Metformin	Small molecule	—	—

Indications

No indication recorded.