drugset
drugset / Trial / NCT07100990

Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

NCT07100990 ↗

Phase 3 Recruiting 382 enrolled Mayo Clinic Patient-Centered Outcomes Research Institute · collab
RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this research is to evaluate if early vs rescue Therapeutic Plasma Exchange (PLEX) treatment algorithm leads to better visual outcomes in severe Optic Neuritis and leads to better neurological disability outcomes in severe Transverse Myelitis.

Timeline

Start
2025-07-11
Primary completion
2029-04-01
Completion
2031-04-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexamethasone Small molecule 176 mg Oral
Comparator Methylprednisolone Other / unclassified 1000 mg Intravenous
Comparator Prednisone Other / unclassified 1250 mg Oral

Indications

optic neuritis transverse myelitis