drugset / Trial / NCT07113691
Iadademstat + SBRT With Atezo in ES-SCLC
Phase 1
Recruiting
15 enrolled
Yale University
Genentech, Inc. · collabOryzon Genomics S.A. · collab
NaSingle-groupOpen-labelTreatment
Summary
This is a phase 1b dose escalation, open-label, non-randomized study of participants with residual, progressive or recurrent ES-SCLC who previously received platinum-based chemotherapy with or without immune checkpoint inhibitor therapy; participants who have achieved only stable disease at the completion of initial platinum-based treatment are eligible for enrollment.
Timeline
- Start
- 2026-01-20
- Primary completion
- 2030-01
- Completion
- 2030-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atezolizumab | Monoclonal antibody | 1680 mg | Intravenous |
| Subject | Iadademstat | Small molecule | 600 ug | Oral |