drugset / Trial / NCT07117760

Prospective Clinical Trial of 225Ac-LNC1011 in the Treatment of Metastatic Castration-Resistant Prostate Cancer

NCT07117760

Phase 1/2 Active not recruiting 16 enrolled First Affiliated Hospital of Fujian Medical University
NaSingle-groupOpen-labelTreatment

Summary

PSMA is an ideal target for precision diagnosis and treatment of prostate cancer. LNC1011 is a novel albumin-binding PSMA-targeted radioligand. This study aims to explore the safety and efficacy of 225Ac-labeled LNC1011 for treating patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC).

Timeline

Start
2025-04-22
Primary completion
2027-12-31
Completion
2029-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject 225Ac-LNC1011 Other / unclassified 3.7 mbq Intravenous
Subject 68Ga-PSMA-11 Diagnostic / imaging agent 150 mbq Intravenous

Indications