Drugs / 68Ga-PSMA-11
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68Ga-PSMA-11

Diagnostic / imaging agent

Investigated by
Mayo Clinic · National Cancer Institute (NCI) · Andrei Iagaru · Telix Pharmaceuticals (Innovations) Pty Limited · First Affiliated Hospital of Fujian Medical University · Jonsson Comprehensive Cancer Center
+67 more · Peking Union Medical College Hospital · Thomas Hope · University of California, San Francisco · Dana Mathews · Anhui Provincial Hospital · General Electric · IRCCS San Raffaele · Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS · National Institutes of Health (NIH) · Novartis Pharmaceuticals · Weill Medical College of Cornell University · ABX CRO · Advanced Nuclear Medicine Ingredients (ANMI) · Ajit H. Goenka, MD · BAMF Health · BSM Diagnostica GmbH Vienna · Cancer Research & Treatment Fund, Inc. · Cancer Targeted Technology · Central Hospital, Nancy, France · Centre de recherche du Centre hospitalier universitaire de Sherbrooke · City of Hope Medical Center · Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Conquer Cancer Foundation · Ebrahim Delpassand · Emory University · Excel Diagnostics and Nuclear Oncology Center · Friedrich-Alexander-Universität Erlangen-Nürnberg · GIE NANCYCLOTEP · Gateway for Cancer Research · German Cancer Research Center · Grand Pharmaceutical (China) Co., Ltd. · Harry S. Truman Memorial Veterans' Hospital · Irene Burger · Jeanne Link · Jules Bordet Institute · M.D. Anderson Cancer Center · Medical University of Vienna · Morand Piert, MD · National Natural Science Foundation of China · OHSU Center of Radiochemistry Research · OHSU Knight Cancer Institute · Oregon Health and Science University · Prostate Cancer Foundation · Radiological Society of North America · Radiomedix, Inc. · Royal Marsden NHS Foundation Trust · Ryan Kohlbrenner, MD · Siemens Healthcare GmbH · Sir Mortimer B. Davis - Jewish General Hospital · Stanford University · Telix Innovations S.A. · The First Affiliated Hospital of Anhui Medical University · The Methodist Hospital Research Institute · Timothy Hoffman · Tulane University · UNC Lineberger Comprehensive Cancer Center · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · United States Department of Defense · University Hospital Freiburg · University of Iowa · University of Michigan · University of Michigan Rogel Cancer Center · University of Missouri-Columbia · University of Saskatchewan · University of Texas Southwestern Medical Center · University of Washington · Varian, a Siemens Healthineers Company

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) ILLUCCIX 2023-03-15 fda.gov
Approved US (FDA) GALLIUM GA 68 GOZETOTIDE 2020-12-01 fda.gov

Trials 77 · started per year

today
US approved 2020
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201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 013 trials
Phase 0 NCT07674771 Jul 2026 → Jun 2029 expected castration-resistant prostate carcinoma University of Texas Southwestern Medical Center Not yet recruiting No outcome recorded
Phase 0 NCT06462508 Apr 2024 → Jun 2025 prostate cancer Anhui Provincial Hospital Unknown No outcome recorded
Phase 0 NCT06437496 Apr → Jul 2024 prostate cancer First Affiliated Hospital of Fujian Medical University Unknown No outcome recorded
Phase 0 NCT05955677 Jul 2023 → Jul 2024 prostate cancer Anhui Provincial Hospital Unknown No outcome recorded
Phase 0 NCT05558956 Nov 2022 → Dec 2023 castration-resistant prostate carcinoma BAMF Health Unknown No outcome recorded
Phase 0 NCT04976257 Oct 2021 → Mar 2023 prostate adenocarcinoma Ryan Kohlbrenner, MD Completed No outcome recorded
Phase 0 NCT04831541 Oct 2020 → Dec 2024 prostate cancer First Affiliated Hospital of Fujian Medical University Unknown No outcome recorded
Phase 0 NCT04801264 Sep 2020 → Sep 2022 adenoid cystic carcinoma Peking Union Medical College Hospital Unknown No outcome recorded
Phase 0 NCT04310540 Jun 2020 → Nov 2023 hepatocellular carcinoma Mayo Clinic Completed No outcome recorded
Phase 0 NCT03982407 Jun 2019 → May 2021 hepatocellular carcinoma Ajit H. Goenka, MD Completed No outcome recorded
Phase 16 trials
Phase 1 NCT06379217 Jul 2024 → Aug 2026 overdue prostate neuroendocrine neoplasm Novartis Pharmaceuticals Active not recruiting No outcome recorded
Phase 1 NCT04750473 Jul 2021 → Mar 2023 female breast carcinoma, invasive lobular breast carcinoma Emory University Completed No outcome recorded
Phase 1 NCT04279561 Apr 2020 → Sep 2022 castration-resistant prostate carcinoma, metastatic prostate carcinoma Jonsson Comprehensive Cancer Center Terminated No outcome recorded
Phase 1 NCT04216134 Dec 2019 → Dec 2022 prostate carcinoma City of Hope Medical Center Completed No outcome recorded
Phase 1 NCT03822871 Apr 2019 → Oct 2022 prostate cancer Cancer Targeted Technology Completed No outcome recorded
Phase 1 NCT03183544 Jan 2019 → Feb 2020 prostate neoplasm Cliniques universitaires Saint-Luc- Université Catholique de Louvain Completed No outcome recorded
Phase 1/27 trials
Phase 1/2 NCT07117760 Apr 2025 → Dec 2027 expected prostate cancer First Affiliated Hospital of Fujian Medical University Active not recruiting No outcome recorded
Phase 1/2 NCT05627778 Nov 2021 → Dec 2022 metastatic prostate carcinoma Peking Union Medical College Hospital Unknown No outcome recorded
Phase 1/2 NCT04614363 Oct 2020 → Feb 2022 prostate cancer The Methodist Hospital Research Institute Completed No outcome recorded
Phase 1/2 NCT03949517 Apr 2019 → Mar 2022 prostate cancer Andrei Iagaru Completed No outcome recorded
Phase 1/2 NCT03545165 Apr 2018 → Jul 2020 prostate cancer Weill Medical College of Cornell University Terminated No outcome recorded
Phase 1/2 NCT03362359 Oct 2017 → Jul 2020 metastatic malignant neoplasm in the lymph nodes, metastatic prostate carcinoma German Cancer Research Center Completed No outcome recorded
Phase 1/2 NCT02488070 Jun → Aug 2015 prostate carcinoma Stanford University Completed No outcome recorded
Phase 225 trials
Phase 2 NCT06444412 Jan 2026 → Jul 2028 expected grade III glioma Mayo Clinic Recruiting No outcome recorded
Phase 2 NCT06560905 Mar → Dec 2025 overdue melanoma Royal Marsden NHS Foundation Trust Recruiting No outcome recorded
Phase 2 NCT06521775 Aug 2024 → Aug 2025 adenoid cystic carcinoma Mayo Clinic Completed No outcome recorded
Phase 2 NCT04243941 Nov 2022 → Feb 2024 prostate cancer UNC Lineberger Comprehensive Cancer Center Withdrawn No outcome recorded
Phase 2 NCT05034562 Sep 2022 metastatic prostate carcinoma M.D. Anderson Cancer Center Withdrawn No outcome recorded
Phase 2 NCT05176223 Jan 2022 → Dec 2025 hepatocellular carcinoma Mayo Clinic Completed No outcome recorded
Phase 2 NCT05214820 Jan 2022 → Dec 2026 expected digestive system cancer Centre de recherche du Centre hospitalier universitaire de Sherbrooke Active not recruiting No outcome recorded
Phase 2 NCT04716725 Sep 2021 → Sep 2023 castration-resistant prostate carcinoma, metastatic prostate carcinoma Thomas Hope Terminated No outcome recorded
Phase 2 NCT04777071 May 2021 → Jul 2025 overdue prostate adenocarcinoma University of Washington Active not recruiting No outcome recorded
Phase 2 NCT04483414 Mar 2021 → Apr 2023 metastatic carcinoma in the bone, metastatic prostate carcinoma Dana Mathews Withdrawn No outcome recorded
Phase 2/35 trials
Phase 2/3 NCT07209878 Jan 2020 → Dec 2025 overdue prostate adenocarcinoma First Affiliated Hospital of Fujian Medical University Recruiting No outcome recorded
Phase 2/3 NCT02673151 May 2017 → Apr 2018 prostate adenocarcinoma Andrei Iagaru Completed No outcome recorded
Phase 2/3 NCT02919111 Sep 2016 → Dec 2019 prostate cancer University of California, San Francisco Completed No outcome recorded
Phase 2/3 NCT02918357 Sep 2016 → Sep 2017 prostate cancer University of California, San Francisco Completed No outcome recorded
Phase 2/3 NCT02678351 Apr 2016 → Dec 2020 prostate adenocarcinoma Andrei Iagaru Completed No outcome recorded
Phase 310 trials
Phase 3 NCT07052214 Aug 2025 → Jun 2026 overdue prostate carcinoma Telix Pharmaceuticals (Innovations) Pty Limited Recruiting No outcome recorded
Phase 3 NCT05847348 Jul 2023 → Dec 2025 overdue prostate carcinoma Telix Pharmaceuticals (Innovations) Pty Limited Recruiting No outcome recorded
Phase 3 NCT04838613 Sep 2021 → Nov 2023 prostate cancer Novartis Pharmaceuticals Completed No outcome recorded
Phase 3 NCT05744115 Jul 2021 → Apr 2022 prostate adenocarcinoma Timothy Hoffman Terminated No outcome recorded
Phase 3 NCT04684628 Dec 2020 → Jan 2025 prostate cancer University of Saskatchewan Suspended No outcome recorded
Phase 3 NCT03623425 Feb 2019 → May 2020 prostate cancer Central Hospital, Nancy, France Unknown No outcome recorded
Phase 3 NCT03803475 Oct 2018 → Aug 2020 prostate cancer Thomas Hope Completed No outcome recorded
Phase 3 NCT03353740 Sep 2017 → Sep 2020 prostate cancer Thomas Hope Completed No outcome recorded
Phase 3 NCT03001869 Jul 2017 → Jul 2023 prostate cancer Sir Mortimer B. Davis - Jewish General Hospital Completed No outcome recorded
Phase 3 NCT02659527 Jan 2016 → May 2022 prostate cancer Medical University of Vienna Completed No outcome recorded
Phase not applicable7 trials
NCT06355843 Apr 2022 → Sep 2023 prostate cancer The First Affiliated Hospital of Anhui Medical University Suspended No outcome recorded
NCT05324332 Apr 2022 → Jan 2025 overdue prostate cancer Peking Union Medical College Hospital Recruiting No outcome recorded
NCT05170555 Dec 2021 → Oct 2022 renal cell carcinoma Peking Union Medical College Hospital Unknown No outcome recorded
NCT05006326 Aug 2021 → Dec 2023 cancer Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Unknown No outcome recorded
NCT03453528 Jul 2017 → Dec 2024 castration-resistant prostate carcinoma Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS Completed No outcome recorded
NCT03187990 Mar 2017 → Aug 2021 prostate cancer Irene Burger Completed No outcome recorded
NCT02920229 Nov 2015 → Oct 2020 prostate cancer Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS Completed No outcome recorded
Phase not stated4 trials
NCT05415228 prostate adenocarcinoma Morand Piert, MD No longer available No outcome recorded
NCT04452136 prostate cancer Jeanne Link Approved for marketing No outcome recorded
NCT05002465 metastatic prostate carcinoma Dana Mathews No longer available No outcome recorded
NCT04854369 castration-resistant prostate carcinoma Tulane University No longer available No outcome recorded
Also used as a comparator or background therapy in 6 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT04886986 Background Jun 2021 → Dec 2027 expected prostate cancer Weill Medical College of Cornell University Recruiting No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT06881823 Comparator Jun 2026 → Mar 2030 prostate cancer Novartis Pharmaceuticals Withdrawn No outcome recorded
Phase 23 trials
Phase 2 NCT05849298 Background Jan 2024 → Dec 2026 expected prostate neoplasm Novartis Pharmaceuticals Active not recruiting No outcome recorded
Phase 2 NCT05658003 Background May 2023 → Dec 2024 overdue prostate carcinoma Novartis Pharmaceuticals Active not recruiting No outcome recorded
Phase 2 NCT03675451 Background Feb 2017 → Jun 2018 prostate cancer Weill Medical College of Cornell University Completed No outcome recorded
Phase 31 trial
Phase 3 NCT05547386 Background May 2022 → Dec 2023 castration-resistant prostate carcinoma, metastatic prostate carcinoma Mayo Clinic Completed No outcome recorded

Evidence & citations 24 cited values

Every value below carries the sentence it was read from. 85 sources stand behind the page.

FieldValueCited text
Known as (68)Ga-PSMA-11 “Glu-NH-CO-NH-Lys-(Ahx)-[(68)Ga(HBED-CC)] ((68)Ga-PSMA-11) is a PET tracer that can detect prostate cancer relapses and metastases by binding to the extracellular domain of PSMA.” PMID 26659347 Dec 2015
27

“Administration of 68Ga-PSMA-11 followed by a PET/CT scan at 45 min after injection.” NCT04684628

“Injection of 68Ga PSMA-11” NCT05002465

NCT03949517

NCT07674771

NCT03822871

NCT03982407

NCT04886986

NCT05415228

NCT05847348

NCT05324332

NCT04483414

NCT07117760

NCT07052214

NCT05558956

NCT05627778

NCT06437496

NCT04716725

NCT04264208

NCT02678351

NCT02673151

NCT03623425

NCT04854369

NCT04179968

NCT03187990

NCT07209878

NCT04831541

NCT03809078

Known as 68Ga PSMA-HBED-CC “This is a study primarily comparing Magnetic Resonance Imaging (MRI) alone to Positron Emission Tomography (PET)/MRI using an experimental tracer, 68Ga-PSMA-HBED-CC, among men...” NCT03439033
6

“This is an expanded access program using 68Ga PSMA-HBED-CC (68Ga-PSMA-11).” NCT05415228

NCT03675451

NCT03545165

NCT04452136

NCT02952469

NCT02659527

Known as 68Ga-HBED-CC-PSMA ClinicalTrials.gov intervention name — accepted as the source's own label NCT03001869
2

NCT04243941

NCT02810886

Known as 68Ga-PSMA “A radiotracer in use today is 68Ga-HBED-CC-PSMA (DKFZ-11) - hereinafter abbreviated 68Ga-PSMA - which is a radiolabeled urea-based ligand for prostate specific membrane antigen...” NCT03001869
15

“To determine the feasibility and utility of Gallium Ga 68-labeled PSMA-11 (68Ga-PSMA) PET imaging in patients with thyroid cancer.” NCT03463889

“100-200 MBq of 68Ga-PSMA will be injected intravenously prior to perform the PET/CT” NCT02920229

NCT04614363

NCT05170555

NCT06355843

NCT05006326

NCT06560905

NCT05214820

NCT05806853

NCT03689582

NCT06484361

NCT03453528

NCT03396874

NCT04801264

NCT02282137

Known as 68gallium-labeled prostate-specific membrane antigen-11 (68-Ga-PSMA-11) 68gallium-labeled prostate-specific membrane antigen-11 (68-Ga-PSMA-11)NCT02673151
Known as [68Ga]Ga-PSMA-11 “two similar PET agents, [68Ga]Ga-P16-093 and [68Ga]Ga-PSMA-11, in the same group of primary prostate cancer (PCa) patients.” PMID 37233785 May 2023
5

NCT06379217

NCT04838613

NCT05658003

NCT06462508

NCT05955677

Known as AAA517 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05849298
Known as DKFZ-11 “A radiotracer in use today is 68Ga-HBED-CC-PSMA (DKFZ-11) - hereinafter abbreviated 68Ga-PSMA - which is a radiolabeled urea-based ligand for prostate specific membrane antigen...” NCT03001869
Known as Ga-68 labeled HBED-CC PSMA ClinicalTrials.gov intervention name — accepted as the source's own label NCT02611882
Known as Ga-68 labeled PSMA-11 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02918357
3

NCT02919111

NCT03353740

NCT03803475

Known as Ga-68-PSMA-11 “The investigators are imaging patients with prostate cancer using a new PET imaging agent (Ga-68-PSMA-11) in order to evaluate its ability to detection prostate cancer in...” NCT03353740
5

NCT06444412

NCT03768349

NCT03362359

NCT05744115

NCT06521775

Known as Gallium (68Ga) gozetotide ClinicalTrials.gov intervention name — accepted as the source's own label NCT06881823
Known as gallium Ga 68 gozetotide “Illuccix (kit for the preparation of gallium Ga 68 gozetotide injection) 68Ga-PSMA-11” NCT05558956
7

NCT04777071

NCT04750473

NCT04762888

NCT05176223

NCT04310540

NCT05547386

NCT04279561

Known as Gallium Ga 68-labeled PSMA Ligand Glu-urea-Lys(Ahx) ClinicalTrials.gov intervention name — accepted as the source's own label NCT02488070
Known as Gallium Ga 68-labeled PSMA-11 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03515577
5

NCT03463889

NCT04216134

NCT05034562

NCT04050215

NCT04282824

Known as Gallium Ga-labeled PSMA-11 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04976257
Known as Gallium-68 labeled HBED-CC PSMA Gallium-68 labeled HBED-CC PSMA (more commonly called 68Ga-PSMA-11) has recently been approved by the FDA for clinical use” NCT05415228
Known as Gallium-68 labeled PSMA-HBED-CC “Subjects have one visit, during which they will undergo one PET/MRI with the study drug, Gallium-68 labeled PSMA-HBED-CC, a radiopharmaceutical” NCT03439033
Known as Gallium-68 PSMA-11 “This is a pilot study to investigate the evaluate to use of a drug/radiopharmaceutical called Gallium-68 PSMA-11 (68Ga-PSMA-11) for use in PET/MRI evaluation of hepatocellular carcinoma” NCT03982407
1

NCT03183544

Known as Glu-NH-CO-NH-Lys-(Ahx)-[(68)Ga(HBED-CC)] Glu-NH-CO-NH-Lys-(Ahx)-[(68)Ga(HBED-CC)] ((68)Ga-PSMA-11) is a PET tracer that can detect prostate cancer relapses and metastases by binding to the extracellular domain of PSMA.” PMID 26659347 Dec 2015
Known as Illuccix Illuccix (kit for the preparation of gallium Ga 68 gozetotide injection) 68Ga-PSMA-11” NCT05558956
Known as PSMA-HBED\_CC “68Ga labeled PSMA -11 (or PSMA-HBED\_CC) PET/MRI scan” NCT03982407
Modality Diagnostic / imaging agent “68Ga-PSMA-11 is a radioactive imaging contrast agent for use in PET CT scan” NCT02282137
Route Intravenous “Patients are injected with 5 mCi of Ga68 PSMA intravenously (IV)” NCT02488070