drugset / Trial / NCT07148622
Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes
RandomizedParallel-groupOpen-labelPrevention
Summary
To investigate the effects of different antibiotic regimens used in preterm premature rupture of membranes (PPROM) on maternal and fetal outcomes after 34 weeks of gestation.
Timeline
- Start
- 2024-10-01
- Primary completion
- 2025-08-01
- Completion
- 2025-08-10
Publications
- Results Lee J, Romero R, Kim SM, Chaemsaithong P, Yoon BH. A new antibiotic regimen treats and prevents intra-amniotic inflammation/infection in patients with preterm PROM. J Matern Fetal Neonatal Med. 2016 Sep;29(17):2727-37. doi: 10.3109/14767058.2015.1103729. Epub 2015 Dec 2.
- Results Sgayer I, Francis YN, Miron D, Shprits E, Sheffer VF, Rechnitzer H, Lowenstein L, Wolf MF. Compared perinatal outcomes of two prophylactic antibiotic regimens for preterm premature rupture of membranes: a randomized controlled trial. Am J Obstet Gynecol MFM. 2023 May;5(5):100900. doi: 10.1016/j.ajogmf.2023.100900. Epub 2023 Feb 13.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ampicillin | Unknown | 2 g | Intravenous |
| Comparator | Azithromycin | Small molecule | 1 g | Oral |
| Comparator | Ceftriaxone | Other / unclassified | 1 g | Intravenous |
| Comparator | Clarithromycin | Small molecule | 500 mg | Oral |
| Comparator | Sulbactam | Small molecule | 2 g | Intravenous |
| Comparator | Amoxicillin | Other / unclassified | 500 mg | Oral |