drugset / Trial / NCT07153003
Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to evaluate the effectiveness and safety of tramadol and oxycodone therapy in comparison to oxycodone alone as part of a multimodal pain regimen to reduce postoperative opioid consumption, pain, minimize adverse events and complications for primary total knee arthroplasty (TKA) and primary total hip arthroplasty (THA).
Timeline
- Start
- 2026-02-02
- Primary completion
- 2030-09-01
- Completion
- 2031-09-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Oxycodone | Other / unclassified | 2.5 mg | Oral |
| Comparator | Oxycodone | Other / unclassified | 5 mg | Oral |
| Comparator | Oxycodone | Other / unclassified | 10 mg | Oral |
| Comparator | Tramadol | Other / unclassified | 50 mg | Oral |
| Comparator | Tramadol | Other / unclassified | 100 mg | Oral |
Indications
No indication recorded.