drugset / Trial / NCT07161414

A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy

NCT07161414

Phase 1 Recruiting 40 enrolled AstraZeneca Parexel · collab
RandomizedSequentialOpen-labelTreatment

Summary

The purpose of this study is to determine the subcutaneous (SC) dose that gives rilvegostomig exposure comparable to the intravenous (IV) exposure, and to evaluate the pharmacokinetics (PK) and safety of SC rilvegostomig in adult participants with advanced solid tumors previously treated with standard of care therapy for whom immunooncology (IO) monotherapy would be deemed appropriate by the investigator.

Timeline

Start
2025-11-25
Primary completion
2027-07-19
Completion
2029-07-24

Drugs

EvaluationDrugModalityDoseRoute
Subject Rilvegostomig Other / unclassified Intravenous
Background rHuPH20 Protein / enzyme biologic Subcutaneous

Indications