drugset / Trial / NCT07165262
Effect of Different Anesthetic Drugs on Electrocorticography (ECOG).
RandomizedParallel-groupQuadruple-blindDiagnostic
Summary
Prospective, double-blind, randomized-controlled study for pediatric cases scheduled for brain tumor excision with the aid of electrocorticography (ECOG). Intraoperative ECOG has been used in an effort to localize the site of epileptogenicity through the demonstration of Interictal Epileptiform Discharges (IED) persistence, frequency, and distribution. During ECOG, pharmaco-activation may be required in order to activate Interictal Epileptiform Abnormalities (IEAs). Frequency of IEAs will be measured for each drug. The effects of anesthetic agents on intraoperative ECOG, as we assume that fentanyl will be superior to ketamine.
Timeline
- Start
- 2025-08-18
- Primary completion
- 2027-03
- Completion
- 2027-03
Publications
- Results Lemieux, L., et al. (2012). "Invasive EEG for Epilepsy Surgery: Current Techniques and Considerations." Journal of Clinical Neurophysiology, 29(3), 246-257.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Fentanyl | Other / unclassified | 1 ug/kg | Intravenous |
| Subject | Ketamine | Small molecule | 0.5 mg/kg | Intravenous |