Letrozole vs Danazol for Endometriosis-Related Pain: Randomized Trial

Summary

Background: Endometriosis is a chronic gynecological condition defined by the ectopic presence of endometrial glands and stroma outside the uterine cavity, most commonly diagnosed via laparoscopy. While its exact etiology remains uncertain, a positive family history is considered a significant risk factor. Danazol has historically demonstrated efficacy in alleviating endometriosis-related pain, while letrozole, primarily used in neoadjuvant settings, has recently emerged as a promising alternative. This study aimed to compare the mean reduction in pain scores between letrozole and danazol in women with laparoscopically confirmed endometriosis. Objective: To compare the efficacy of letrozole versus danazol in reducing pain scores among women diagnosed with endometriosis. Material \& Methods: Study Design: Randomized control trial Setting: Department of Obstetrics \& Gynaecology, Sharif Medical and Dental Hospital

Timeline

Start

2019-04-10

Primary completion

2019-10-10

Completion

2025-07-31

Publications

• Background Haqnawaz F, Virk S, Qadir T, Imam S, Rizvi J. Comparison of Letrozole and Clomiphene Citrate Efficacy along with Gonadotrophins in Controlled Ovarian Hyperstimulation for Intrauterine Insemination Cycles. J Reprod Infertil. 2013 Jul;14(3):138-42.
• Background García E, Cruz OP. Regulation of Inflammation Pathways and Inflammasome by Sex Steroid. Reproduction and the Inflammatory Response. 2022:607539061.
• Background Khashchenko EP, Uvarova EV, Fatkhudinov TK, Chuprynin VD, Asaturova AV, Kulabukhova EA, Vysokikh MY, Allakhverdieva EZ, Alekseeva MN, Adamyan LV, Sukhikh GT. Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features. J Clin Med. 2023 Feb 20;12(4):1678. doi: 10.3390/jcm12041678.
• Background Arafah M, Rashid S, Akhtar M. Endometriosis: A Comprehensive Review. Adv Anat Pathol. 2021 Jan;28(1):30-43. doi: 10.1097/PAP.0000000000000288.
• Results Rasul SG, Yaqub U, Manzoor M, Mubasshar H. Comparison of Letrozole versus Danazol for the pain management of females presented with endometriosis. Annals of King Edward Medical University. 2017;23(4):514-8.
• Results Mehmud G, Akhtar T, Sadia S. Endometriosis: frequency and correlation between symptomatology and disease stage. J Coll Physicians Surg Pak. 2007 Apr;17(4):199-202.

Drugs

Indications