drugset / Trial / NCT07226453
Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma
Phase 2
Recruiting
30 enrolled
University of California, San Francisco
Pediatric Neuro-Oncology Consortium · collabThe Lilabean Foundation, Inc. · collab
Non-randomizedSequentialOpen-labelTreatment
Summary
This is a multi-site study of the pharmacodynamic effects and efficacy of metformin in children and young adults with recurrent or progressive Posterior Fossa Group A (PFA) ependymoma.
Timeline
- Start
- 2026-05-05
- Primary completion
- 2028-04-30
- Completion
- 2030-03-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Metformin | Small molecule | 1666 mg/m2 | Oral |