Anrikefon-based Patient-controlled Intravenous Analgesia After Laparoscopic Surgery

Summary

Visceral pain following laparoscopic surgery is frequently underestimated, yet it is associated with a range of adverse outcomes. Effective visceral pain management should constitute an essential component of postoperative analgesic strategies following laparoscopic procedures. However, conventional analgesic agents, including μ-opioid receptor agonists, lack specificity for visceral pain. Anrikefon, a novel selective peripheral κ-opioid receptor agonist, demonstrates unique efficacy in alleviating visceral pain with a favorable safety profile. Preliminary studies showed that a single intravenous dose of anrikefon effectively alleviates postoperative pain after abdominal surgery with a low risk of adverse effects. The investigators hypothesize that an appropriate dosing regimen of anrikefon administered via patient-controlled intravenous analgesia (PCIA) pump, as part of a multimodal analgesic strategy, can specifically target and alleviate visceral pain after laparoscopic surgery, thereby achieving comprehensive postoperative analgesia.

Timeline

Start

2025-12-25

Primary completion

2026-02-11

Completion

2026-03-11

Outcome

Outcome not reported

Stopped: “The study was terminated due to substantial protocol amendments involving changes in the target population and primary endpoint, rendering previously collected data incompatible with the revised study objective.”

Publications

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Drugs

Indications

No indication recorded.