drugset / Trial / NCT07262554
N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis
RandomizedParallel-groupSingle-blindTreatment
Summary
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as an intracanal and adjunctive systemic medication, versus calcium hydroxide (Ca(OH)₂) intracanal medication alone.
Timeline
- Start
- 2025-11-15
- Primary completion
- 2026-06
- Completion
- 2026-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Calcium Hydroxide | Other / unclassified | — | Other |
| Subject | N-acetylcysteine | Small molecule | 600 mg | Other |