Drugs / Calcium Hydroxide
Calcium Hydroxide
also known as
Ca(OH)2 · Calcium Hydroxide (Ca(OH)2) · Dycal · metapaste · Calacept · Calcarea caustica · Calcium hydroxide solution · Dycal\_ Ivory · +6 more
Trials 25 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 22 trials | ||||||
| Phase 2 | NCT02824601 | Feb 2015 → Apr 2016 | tooth disorder | São Paulo State University | Completed | No outcome recorded |
| Phase 2 | NCT01730287 | May 2010 → Dec 2012 | dental pulp necrosis | Azad University of Medical Sciences | Unknown | No outcome recorded |
| Phase 2/32 trials | ||||||
| Phase 2/3 | NCT04319575 | Dec 2018 → Apr 2020 | suppurative periapical periodontitis | Dr. D. Y. Patil Dental College & Hospital | Unknown | No outcome recorded |
| Phase 2/3 | NCT03849222 | Aug 2013 → Apr 2016 | dental pulp necrosis | Al-Azhar University | Completed | No outcome recorded |
| Phase 44 trials | ||||||
| Phase 4 | NCT07683520 | Oct 2025 → Jun 2026 | chronic apical periodontitis | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT04900571 | Jan → May 2021 | neuropathy, painful, pulpitis | Altamash Institute of Dental Medicine | Completed | No outcome recorded |
| Phase 4 | NCT03084601 | Mar 2017 → Jan 2018 | dental pulp necrosis | Mahmoud M Saadoon | Completed | No outcome recorded |
| Phase 4 | NCT03426046 | Nov 2013 → Apr 2016 | dental caries | Didem Sakaryali | Completed | No outcome recorded |
| Phase not applicable17 trials | ||||||
| — | NCT07239739 | Jun → Nov 2026 expected | periapical periodontitis | Faiz ur rahman | Not yet recruiting | No outcome recorded |
| — | NCT07585721 | Jun 2026 → Feb 2027 expected | periapical periodontitis | Future University in Egypt | Not yet recruiting | No outcome recorded |
| — | NCT07571837 | Feb 2026 → Jan 2027 expected | periapical periodontitis | Al-Azhar University | Recruiting | No outcome recorded |
| — | NCT07071675 | Sep 2025 → Aug 2026 overdue | type 2 diabetes mellitus | Minia University | Not yet recruiting | No outcome recorded |
| — | NCT07141459 | Aug 2025 → Sep 2026 expected | periapical periodontitis | Al-Azhar University | Recruiting | No outcome recorded |
| — | NCT06625645 | Jan → May 2025 overdue | dental pulp necrosis, periapical periodontitis | Mahy Abdel Raouf Aly Kamar | Not yet recruiting | No outcome recorded |
| — | NCT06447519 | Sep 2024 → Sep 2026 expected | — | Aristotle University Of Thessaloniki | Active not recruiting | No outcome recorded |
| — | NCT07123792 | Jun 2024 → May 2025 | periodontal disorder | HITEC-Institute of Medical Sciences | Completed | No outcome recorded |
| — | NCT06653608 | Apr → Sep 2024 | acute apical periodontitis, dental pulp necrosis | Pakistan Institute of Medical Sciences | Completed | No outcome recorded |
| — | NCT06253247 | Apr → Jun 2024 | — | Cairo University | Unknown | No outcome recorded |
| — | NCT06632015 | Jan → May 2024 | acute apical periodontitis | Mustafa Kemal University | Completed | No outcome recorded |
| — | NCT06174909 | Nov 2022 → Aug 2023 | — | Pakistan Institute of Medical Sciences | Completed | No outcome recorded |
| — | NCT05581706 | Sep 2017 → Feb 2020 | — | Ege University | Completed | No outcome recorded |
| — | NCT03064191 | Sep 2017 → Mar 2018 | tooth disorder | rayan rabie dahab | Unknown | No outcome recorded |
| — | NCT03403985 | Jun 2017 | dental caries, dental pulp disorder | Jordan University of Science and Technology | Unknown | No outcome recorded |
| — | NCT03009006 | Jan → Oct 2017 | dental pulp necrosis | Cairo University | Unknown | No outcome recorded |
| — | NCT03606681 | Jul 2013 → Jun 2014 | dental pulp disorder | Altinbas University | Completed | No outcome recorded |
Also used as a comparator or background therapy in 53 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 06 trials | ||||||
| Phase 0 | NCT07603934 Comparator | Dec 2025 → Aug 2026 overdue | dental pulp necrosis | Cairo University | Recruiting | No outcome recorded |
| Phase 0 | NCT07101029 Comparator | Aug 2025 → Jul 2026 overdue | acute apical periodontitis | Cairo University | Not yet recruiting | No outcome recorded |
| Phase 0 | NCT07423663 Comparator | Sep 2024 → Mar 2026 overdue | periapical periodontitis | Suez Canal University | Active not recruiting | No outcome recorded |
| Phase 0 | NCT05687760 Comparator | Feb 2023 | — | Cairo University | Unknown | No outcome recorded |
| Phase 0 | NCT05666089 Comparator | Feb 2023 → Feb 2024 | — | Cairo University | Unknown | No outcome recorded |
| Phase 0 | NCT03209115 Comparator | Jul → Sep 2017 | — | Cairo University | Unknown | No outcome recorded |
| Phase 11 trial | ||||||
| Phase 1 | NCT07641933 Comparator | Jun 2026 → Jun 2027 expected | suppurative periapical periodontitis | Ain Shams University | Recruiting | No outcome recorded |
| Phase 25 trials | ||||||
| Phase 2 | NCT07262554 Comparator | Nov 2025 → Jun 2026 overdue | periodontitis | Alexandria University | Active not recruiting | No outcome recorded |
| Phase 2 | NCT06342830 Comparator | Jun 2024 → Sep 2025 | periapical periodontitis | Ain Shams University | Completed | No outcome recorded |
| Phase 2 | NCT07437612 Comparator | Feb 2023 → Jan 2024 | periapical periodontitis | Celalettin Topbaş | Completed | No outcome recorded |
| Phase 2 | NCT03327844 Comparator | Mar 2017 → Jul 2021 | — | National University Health System, Singapore | Completed | No outcome recorded |
| Phase 2 | NCT04213716 Background | Jun 2015 → Jun 2016 | — | Cairo University | Completed | No outcome recorded |
| Phase 2/38 trials | ||||||
| Phase 2/3 | NCT06207253 Comparator | Nov → Dec 2025 overdue | dental pulp disorder | British University In Egypt | Recruiting | No outcome recorded |
| Phase 2/3 | NCT06821763 Comparator | May → Oct 2025 overdue | periodontitis, pulpitis | Komal Ashraf Khan | Not yet recruiting | No outcome recorded |
| Phase 2/3 | NCT06196515 Comparator | Aug 2024 → Sep 2025 overdue | dental pulp disorder | British University In Egypt | Recruiting | No outcome recorded |
| Phase 2/3 | NCT06566508 Comparator | Nov 2023 → Jun 2024 overdue | — | Mansoura University | Recruiting | No outcome recorded |
| Phase 2/3 | NCT06466538 Comparator | Jun 2022 → Jul 2024 | — | Mansoura University | Unknown | No outcome recorded |
| Phase 2/3 | NCT06453304 Comparator | Mar 2022 → Jun 2024 | — | Mansoura University | Unknown | No outcome recorded |
| Phase 2/3 | NCT02492841 Comparator | Apr 2014 → Apr 2016 | dental caries, exposure, dental pulp | Universidad de los Andes, Chile | Completed | No outcome recorded |
| Phase 2/3 | NCT01468480 Comparator | Jun 2010 → Feb 2011 | exposure, dental pulp | Islamic Azad University, Sanandaj | Completed | No outcome recorded |
| Phase 34 trials | ||||||
| Phase 3 | NCT05928858 Comparator | Sep 2023 → Jun 2024 | dental pulp calcification | Cairo University | Unknown | No outcome recorded |
| Phase 3 | NCT03700788 Comparator | May 2023 → Jun 2025 | periodontitis | University of Southern California | Unknown | No outcome recorded |
| Phase 3 | NCT03723980 Comparator | Nov 2017 → Apr 2018 | — | Juzer Shabbir Saifee | Completed | No outcome recorded |
| Phase 3 | NCT00472173 Comparator | May 2007 → Nov 2010 | dental pulp necrosis | Assistance Publique - Hôpitaux de Paris | Completed | No outcome recorded |
| Phase 47 trials | ||||||
| Phase 4 | NCT07388888 Comparator | Feb 2026 → Feb 2027 expected | dental pulp necrosis | Ain Shams University | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT06683833 Comparator | Sep 2025 → May 2026 overdue | dental caries | Cairo University | Recruiting | No outcome recorded |
| Phase 4 | NCT06807320 Comparator | Jan 2022 → Jan 2024 | dental pulp calcification | Shaheed Zulfiqar Ali Bhutto Medical University | Completed | No outcome recorded |
| Phase 4 | NCT05021809 Comparator | Jul 2021 → Sep 2022 | periapical periodontitis | Suez Canal University | Unknown | No outcome recorded |
| Phase 4 | NCT03692286 Comparator | Jun 2019 → Aug 2020 | — | Cairo University | Completed | No outcome recorded |
| Phase 4 | NCT05222243 Comparator | Jan 2019 → Aug 2020 | dental pulp disorder | Mansoura University | Completed | No outcome recorded |
| Phase 4 | NCT03042377 Comparator | Mar → Jul 2015 | acute apical periodontitis, tooth disorder | Istanbul Medipol University Hospital | Completed | No outcome recorded |
| Phase not applicable22 trials | ||||||
| — | NCT07578311 Comparator | Jul 2026 → Jan 2027 expected | — | Minia University | Not yet recruiting | No outcome recorded |
| — | NCT07495605 Comparator | Mar 2026 → Dec 2027 expected | — | Cairo University | Not yet recruiting | No outcome recorded |
| — | NCT07371416 Background | Oct 2025 → Dec 2026 expected | dental pulp necrosis | Mansoura University | Active not recruiting | No outcome recorded |
| — | NCT07396688 Comparator | Sep 2025 → Feb 2026 | — | Ankara University | Completed | No outcome recorded |
| — | NCT07183514 Comparator | Sep → Dec 2025 overdue | dental pulp calcification | University of Health Sciences Lahore | Not yet recruiting | No outcome recorded |
| — | NCT06755502 Comparator | Aug 2025 → Oct 2026 expected | pulpitis | Cairo University | Not yet recruiting | No outcome recorded |
| — | NCT07252258 Comparator | Jul 2025 → Feb 2026 overdue | periapical periodontitis | Aqsa Afzal | Active not recruiting | No outcome recorded |
| — | NCT06779370 Comparator | Jun → Dec 2024 | — | Ataturk University | Completed | No outcome recorded |
| — | NCT06307678 Comparator | Jul → Dec 2023 | periapical periodontitis | Ataturk University | Completed | No outcome recorded |
| — | NCT07332936 Comparator | Jul 2023 → Jun 2024 | acute apical periodontitis, pulpitis | Umm Al-Qura University | Completed | No outcome recorded |
| — | NCT05525013 Comparator | Oct 2022 → Jun 2024 | periapical periodontitis | Cairo University | Completed | No outcome recorded |
| — | NCT07340944 Comparator | Sep 2022 → Jan 2023 | chronic apical periodontitis | Ataturk University | Completed | No outcome recorded |
| — | NCT04763057 Comparator | Apr → Sep 2021 | dental caries | Cairo University | Unknown | No outcome recorded |
| — | NCT04593238 Comparator | Nov 2020 → Apr 2021 | — | Cairo University | Unknown | No outcome recorded |
| — | NCT04005872 Comparator | Oct 2019 → Nov 2022 | dental caries | Cairo University | Completed | No outcome recorded |
| — | NCT04673916 Comparator | Jun 2019 → Feb 2020 | lichen planus, oral, preneoplastic lesion | University of Messina | Completed | No outcome recorded |
| — | NCT04000854 Comparator | Feb 2019 → Dec 2023 | — | Karolinska Institutet | Unknown | No outcome recorded |
| — | NCT03724266 Comparator | Oct 2018 → May 2020 | — | Cairo University | Unknown | No outcome recorded |
| — | NCT03488316 Comparator | May → Jul 2018 | — | PAULO VINICIUS SOARES | Unknown | No outcome recorded |
| — | NCT04983524 Comparator | Oct 2015 → May 2018 | chronic pain syndrome, dental pulp necrosis | Cairo University | Completed | No outcome recorded |
| — | NCT03631277 Comparator | Jan 2015 → Jan 2017 | dental caries | Cairo University | Completed | No outcome recorded |
| — | NCT00812877 Comparator | May 2009 → May 2012 | exposure, dental pulp | Oregon Health and Science University | Completed | No outcome recorded |
Evidence & citations 18 cited values
Every value below carries the sentence it was read from. 79 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Calcium hydroxide | “It contains calcium hydroxide, hyaluronic acid, Umbelliferone and Oligomeric Proanthocyanidins.” NCT04673916 ↗70“using Chitosan mixed with calcium hydroxide or Triple Antibiotic Paste at 3,6 and 12 months.” NCT04319575 ↗ “between intracanal medicaments Nitrofurantoin and Calcium Hydroxide Paste” NCT04900571 ↗ “Partial pulpotomy treatment with Calcium Hydroxide” NCT03426046 ↗ |
| Known as | Ca(OH)2 | “Use of 2% Chlorhexidine (CHX) as Intracanal Medicament in Endodontic Emergencies and to Compare Its Use and Effectiveness With CaOH2 (CH) Calcium Hydroxide Paste” NCT03700788 ↗17“Experimental group Ca (OH) 2 ( Ca (OH) 2with nanosilver suspension and comparison group Ca (OH) 2 with sterile water” NCT04213716 ↗ “Calcium hydroxide (Ca(OH)2) is considered as a universal intracanal medicament for this purpose .” NCT05021809 ↗ “Calcium hydroxide (Ca(OH)2) has been used extensively in dentistry since the 1920s (17).” NCT06453304 ↗ “Calcium hydroxide [Ca(OH)2] is the most commonly used intracanal medication.” NCT06466538 ↗ “Calcium Hydroxide (Ca(OH)2) Intracanal Medication” NCT07641933 ↗ “calcium hydroxide (Ca(OH)₂)-treated group” NCT07340944 ↗ “intracanal medication of Ca(OH)2 paste” NCT05666089 ↗ “Drug: Calcium Hydroxide (Ca(OH)2)” NCT07495605 ↗ “Calcium Hydroxide (Ca(OH)2)” NCT07332936 ↗ “Calcium Hydroxide (Ca(OH)2)” NCT07239739 ↗ “Calcium Hydroxide (Ca(OH)2)” NCT06807320 ↗ “Calcium Hydroxide (Ca(OH)2)” NCT06683833 ↗ “Calcium Hydroxide (Ca(OH)2)” NCT07388888 ↗ “calcium hydroxide Ca(OH)2” NCT06566508 ↗ |
| Known as | Calacept | “Calcium hydroxide (Calacept)” NCT04000854 ↗ |
| Known as | Calcarea caustica | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106388 ↗ |
| Known as | Calcium Hydroxide (Ca(OH)2) | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03403985 ↗ |
| Known as | Calcium hydroxide solution | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106388 ↗ |
| Known as | Dycal | “calcium hydroxide( Dycal ® Dentsply Caulk )was applied using calcium hydroxide applicator followed by glass ionomer and then composite resin as a final restoration” NCT03631277 ↗ |
| Known as | Dycal\_ Ivory | “For Group I patients, Calcium hydroxide (Dycal\_ Ivory,Dentsply Caulk, Dentsply, L.D. Caulk, Milford, DE,USA ) was used.” NCT06807320 ↗ |
| Known as | E-526 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106388 ↗ |
| Known as | INS NO.526 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106388 ↗ |
| Known as | INS-526 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106388 ↗ |
| Known as | Lime hydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106388 ↗ |
| Known as | Lime water | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106388 ↗ |
| Known as | metapaste | “intracanal medication of calcium hydroxide paste (metapaste)” NCT05666089 ↗1“Metapaste [calcium hydroxide paste (control group)]” NCT06342830 ↗ |
| Known as | Slaked lime | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106388 ↗ |
| Action | Inhibit | “Ca(OH)2 also inactivates lipopolysaccharide so it can assist in periapical tissue repair (19).” NCT06453304 ↗ |
| Modality | Other / unclassified | “Inorganic compound (CA(OH)2.” NCT02492841 ↗ |
| Route | Other | “calcium hydroxide intracanal medication alone for 2 weeks period” NCT03009006 ↗ |