Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing
Summary
The goal of this clinical trial is to compare the effects of different intracanal medication between endodontic retreatment visits in previously failed root canal treatment patients (single root canal anteriors or premolars teeth). The main question it aims to answer are: * Is natural and synthetic intracanal Medicament effective in reducing or complete healing of Periapical lesions or not? the researchers will compare the effect of different intracanal dressing including: * nanocurcumin gel * curcumin gel * ciprofloxacin +ibuprofen gel * calcium hydroxide Paste as control group in between the endodontic retreatment visits to see if these medicaments work well on periapical lesion healing this outcome measured by Cone beam CT at base and after 1 year follow up period
Timeline
- Start
- 2024-06-20
- Primary completion
- 2025-09-20
- Completion
- 2025-10-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Calcium Hydroxide | Other / unclassified | — | Other |
| Subject | Ciprofloxacin | Small molecule | 500 mg | Other |
| Subject | Curcumin | Small molecule | 250 mg | Other |
| Subject | Ibuprofen | Small molecule | 400 mg | Other |
| Subject | Nanocurcumin | Unknown | 0.3 % | Other |