Evaluation of the Aloe Vera Anti-inflammatory Effect on Apical Periodontitis.

Summary

The goal of this clinical trial is to evaluation aloe vera as intracanal medication anti-inflammatory also inter-appointment pain incidence compared with calcium hydroxide. The main questions it aims to answer are: Does aloe vera reduced pro-inflammatory cytokine (IL-1b)? Researchers will compare aloe vera to calcium hydroxide intra-canal medication to see if it works to modulate the inflammatory response in necrotic teeth with apical periodontitis. Participants will: Receive the intra-canal medications following root canal preparation for 14 days, periapical tissue fluid samples will be collected after access cavity preparation and 14days post medication placement. Pre-operative pain level and 24h, 48h post medication placement will be recorded.

Timeline

Start

2024-08-05

Primary completion

2026-02-17

Completion

2026-02-17

Publications

• Background Virdee SS, Butt K, Grant M, Camilleri J, Cooper PR, Tomson PL. A systematic review of methods used to sample and analyse periradicular tissue fluid during root canal treatment. Int Endod J. 2019 Aug;52(8):1108-1127. doi: 10.1111/iej.13104. Epub 2019 Mar 27.
• Background Parashar V, Khan SA, Singh P, Sharma S, Kumar A, Kumar A. Effect of Intracanal Medicaments (Modified Triple Antibiotic Paste, Calcium Hydroxide, and Aloe Vera) on Microhardness of Root Dentine: An In Vitro Study. J Contemp Dent Pract. 2020 Jun 1;21(6):632-635.
• Background Abbaszadegan A, Sahebi S, Gholami A, Delroba A, Kiani A, Iraji A, Abbott PV. Time-dependent antibacterial effects of Aloe vera and Zataria multiflora plant essential oils compared to calcium hydroxide in teeth infected with Enterococcus faecalis. J Investig Clin Dent. 2016 Feb;7(1):93-101. doi: 10.1111/jicd.12123. Epub 2014 Sep 4.
• Background Arunkumar S, Muthuselvam M. Analysis of phytochemical constituents and antimicrobial activities of Aloe vera L. against clinical pathogens. World J Agric Sci 2009;5:572-6
• Background Barbosa-Ribeiro M, Arruda-Vasconcelos R, de-Jesus-Soares A, Zaia AA, Ferraz CCR, de Almeida JFA, Gomes BPFA. Effectiveness of calcium hydroxide-based intracanal medication on infectious/inflammatory contents in teeth with post-treatment apical periodontitis. Clin Oral Investig. 2019 Jun;23(6):2759-2766. doi: 10.1007/s00784-018-2719-0. Epub 2018 Oct 26.
• Background Martinho FC, Gomes CC, Nascimento GG, Gomes APM, Leite FRM. Clinical comparison of the effectiveness of 7- and 14-day intracanal medications in root canal disinfection and inflammatory cytokines. Clin Oral Investig. 2018 Jan;22(1):523-530. doi: 10.1007/s00784-017-2143-x. Epub 2017 Jun 6.
• Background Silva TA, Garlet GP, Fukada SY, Silva JS, Cunha FQ. Chemokines in oral inflammatory diseases: apical periodontitis and periodontal disease. J Dent Res. 2007 Apr;86(4):306-19. doi: 10.1177/154405910708600403.
• Background Hussein H, Kishen A. Local Immunomodulatory Effects of Intracanal Medications in Apical Periodontitis. J Endod. 2022 Apr;48(4):430-456. doi: 10.1016/j.joen.2022.01.003. Epub 2022 Jan 13.
• Background Arias Z, Nizami MZI, Chen X, Chai X, Xu B, Kuang C, Omori K, Takashiba S. Recent Advances in Apical Periodontitis Treatment: A Narrative Review. Bioengineering (Basel). 2023 Apr 19;10(4):488. doi: 10.3390/bioengineering10040488.

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Indications