drugset / Trial / NCT07262814
Efficacy and Safety of Ascending Doses of Arpraziquantel in Children Infected With Opisthorchis Viverrini
Phase 2
Not yet recruiting
125 enrolled
Jennifer Keiser
Lao Tropical and Public Health Institute · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
This study aims to assess the efficacy, safety and acceptability of ascending doses of arpraziquantel in children infected with Opisthorchis viverrini. The primary objective is to determine the dose-response relationship in terms of cure rate. This study will involve children aged 6-7 years, since O. viverrini infections often occur in pre-school and school-aged children, and this group is largely left untreated in current public health programs.
Timeline
- Start
- 2026-07-20
- Primary completion
- 2026-10
- Completion
- 2026-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | arpraziquantel | Small molecule | 20 mg/kg | Oral |
| Subject | arpraziquantel | Small molecule | 30 mg/kg | Oral |
| Subject | arpraziquantel | Small molecule | 40 mg/kg | Oral |
| Subject | arpraziquantel | Small molecule | 50 mg/kg | Oral |
| Subject | arpraziquantel | Small molecule | 60 mg/kg | Oral |