drugset / Trial / NCT07271186

Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

NCT07271186 ↗

Phase 2 Recruiting 270 enrolled Regeneron Pharmaceuticals
RandomizedParallel-groupQuadruple-blindTreatment

Summary

This study is researching experimental drugs called ALN-ANG3 and evinacumab (called "study drugs"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times

Timeline

Start
2026-01-09
Primary completion
2027-09-24
Completion
2028-04-07

Drugs

EvaluationDrugModalityDoseRoute
Subject ALN-ANG3 Small interfering RNA (siRNA) — —
Subject Evinacumab Monoclonal antibody — —