drugset / Trial / NCT07281209

A Study of SHR-A1811 Combined With Adebelimumab as Neoadjuvant Therapy for Resectable HER2-Altered Non-Small Cell Lung Cancer

NCT07281209

Phase 2 Not yet recruiting 40 enrolled Shanghai Chest Hospital
NaSingle-groupOpen-labelTreatment

Summary

This is a prospective, single-arm, multi-center Phase II clinical trial designed to evaluate the efficacy and safety of neoadjuvant therapy with SHR-A1811 in combination with Adebelimumab in patients with resectable, early-stage non-small cell lung cancer (NSCLC) harboring HER2 alterations.

Timeline

Start
2025-12
Primary completion
2027-12
Completion
2029-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Adebrelimab Monoclonal antibody
Subject Trastuzumab Rezetecan Monoclonal antibody