drugset / Trial / NCT07286149

A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)

NCT07286149

Phase 1/2 Recruiting 190 enrolled Merck Sharp & Dohme LLC Daiichi Sankyo · collab
RandomizedSequentialOpen-labelTreatment

Summary

Researchers want to learn if MK-1084, the study medicine, can treat advanced or metastatic non-squamous NSCLC. MK-1084 is a targeted therapy, which is a treatment that works to control how specific types of cancer cells grow and spread. The goals of this study are to learn: * About the safety of MK-1084 and if people tolerate it when taken with other treatments * How many people have the cancer respond (get smaller or go away) to the treatments

Timeline

Start
2026-04-30
Primary completion
2031-08-11
Completion
2032-04-13

Drugs

EvaluationDrugModalityDoseRoute
Subject Calderasib Unknown Oral
Subject Cetuximab Monoclonal antibody Intravenous
Subject Patritumab deruxtecan Monoclonal antibody Intravenous
Subject Sacituzumab Tirumotecan Other / unclassified Intravenous

Indications