drugset / Trial / NCT07296718

Single Vs Multi-strain Probiotics for Preterm Neonates

NCT07296718

Phase 4 Completed 249 enrolled Madiha, MPhil
RandomizedParallel-groupQuadruple-blindDiagnostic

Summary

The goal of this randomized control clinical trial is to determine if probiotics can prevent mortality and morbidity in preterm neonates. It also evaluates effects of probiotics on feeding pattern and growth. It will also learn about the comparative effects of single vs multiple strain probiotics. It aims to answer: Does probiotics improve the health and growth outcomes in preterm neonates in our population? Does single vs multiple strain of probiotics have difference in effects? Participants will: Participants given either single strain or multiple strain probiotics for 28 days post birth. Data about mortality, morbidity, feeding pattern and growth (weight, height, head circumference gain) recorded on daily basis.

Timeline

Start
2023-05-15
Primary completion
2023-11-15
Completion
2025-10-15

Drugs

EvaluationDrugModalityDoseRoute
Comparator BB-12 Unknown Oral
Comparator L casei-431 Unknown Oral
Comparator Lactobacillus paracasei Unknown Oral
Comparator Lactobacillus rhamnosus GG Other / unclassified 3e+09 cells Oral
Comparator Streptococcus thermophilus TH-4 Unknown Oral