drugset / Trial / NCT07310433

Dapagliflozin Combined With Next-generation Hormonal Agent (NHA) Versus Single NHA in Participants With Metastatic Castrate-resistant Prostate Cancer

NCT07310433

Phase 2 Not yet recruiting 60 enrolled Yung NA Huashan Hospital · collabRuijin Hospital · collab
RandomizedParallel-groupOpen-labelTreatment

Summary

Dapagliflozin is a well-established medication being marketed and used for treatment Type 2 diabetes mellitus (T2DM). In retrospective cohort studies done by our team, we found that metastatic prostate cancer patients who received Dapagliflozin together with standard anti-cancer treatment, androgen deprivation therapy (ADT) combined with novel hormonal agent (NHA), had better tumor control than those having ADT and NHA.

Timeline

Start
2026-06-01
Primary completion
2029-10-30
Completion
2030-10-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Dapagliflozin Small molecule 10 mg