drugset / Trial / NCT07323043

Effect of Tegileridine Versus Sufentanil as Analgesic Components on Opioid-Induced Cough During Anesthesia Induction

NCT07323043

RandomizedParallel-groupDouble-blindOther

Summary

In patients undergoing general anesthesia with planned tracheal intubation , a prospective, randomized, controlled study was conducted to record the occurrence of cough 2 minutes after injection of Sufentanil or Tegilerdine. The cough was graded based on the frequency and duration: Grade I, no cough; Grade II, a single mild cough; Grade III, multiple coughs with duration \<1 second; Grade IV, continuous coughing with a duration \>15 seconds.

Timeline

Start
2026-01-15
Primary completion
2026-08-16
Completion
2026-10-13

Drugs

EvaluationDrugModalityDoseRoute
Comparator Sufentanil Other / unclassified 0.2 ug/kg Intravenous
Comparator Sufentanil Other / unclassified 0.4 ug/kg Intravenous
Subject Tegilerdine Unknown 20 ug/kg Intravenous
Subject Tegilerdine Unknown 50 ug/kg Intravenous