drugset / Trial / NCT07323043
Effect of Tegileridine Versus Sufentanil as Analgesic Components on Opioid-Induced Cough During Anesthesia Induction
RandomizedParallel-groupDouble-blindOther
Summary
In patients undergoing general anesthesia with planned tracheal intubation , a prospective, randomized, controlled study was conducted to record the occurrence of cough 2 minutes after injection of Sufentanil or Tegilerdine. The cough was graded based on the frequency and duration: Grade I, no cough; Grade II, a single mild cough; Grade III, multiple coughs with duration \<1 second; Grade IV, continuous coughing with a duration \>15 seconds.
Timeline
- Start
- 2026-01-15
- Primary completion
- 2026-08-16
- Completion
- 2026-10-13
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Sufentanil | Other / unclassified | 0.2 ug/kg | Intravenous |
| Comparator | Sufentanil | Other / unclassified | 0.4 ug/kg | Intravenous |
| Subject | Tegilerdine | Unknown | 20 ug/kg | Intravenous |
| Subject | Tegilerdine | Unknown | 50 ug/kg | Intravenous |