Propofol vs Remifentanil for Sedation in Gastroscopy
Summary
This prospective randomized study aims to compare propofol and remifentanil for sedation during elective diagnostic gastroscopy. The ideal sedative agent for gastroscopy should provide adequate sedation, rapid recovery, patient safety, and high endoscopist satisfaction. Although propofol is widely used for procedural sedation, remifentanil's ultra-short pharmacokinetic profile may offer advantages in short procedures such as gastroscopy. However, comprehensive comparative data evaluating recovery quality, safety, and procedural conditions between these agents remain limited. This study evaluates sedation efficacy, recovery characteristics, complication rates, and endoscopist satisfaction associated with propofol- and remifentanil-based sedation protocols.
Timeline
- Start
- 2026-02-02
- Primary completion
- 2026-04-01
- Completion
- 2026-04-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propofol | Small molecule | 100 ug/kg | Intravenous |
| Comparator | Propofol | Small molecule | 150 ug/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.025 ug/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.1 ug/kg | Intravenous |
Indications
No indication recorded.