drugset / Trial / NCT07337772
Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to explore the safety and feasibility of high-dose glucocorticoids. Through this research, the investigators hope to provide an optimized solution for post-TKA pain management, improve patients' postoperative recovery and quality of life, and offer scientific evidence for pain management following TKA.
Timeline
- Start
- 2026-02-01
- Primary completion
- 2028-11-01
- Completion
- 2028-11-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Betamethasone | Other / unclassified | 5 mg | Other |
| Subject | Betamethasone | Other / unclassified | 10 mg | Other |
| Subject | Betamethasone | Other / unclassified | 15 mg | Other |
| Subject | betamethasone dipropionate | Small molecule | 2 mg | Other |
| Subject | betamethasone dipropionate | Small molecule | 4 mg | Other |
| Subject | betamethasone dipropionate | Small molecule | 6 mg | Other |