drugset / Trial / NCT07359859

A Study of Ruxolitinib for Preventing Graft-Versus-Host Disease in People With a Hematologic Malignancy Who Will Receive a Stem Cell Transplant

NCT07359859

RandomizedParallel-groupOpen-labelPrevention

Summary

The researchers are doing this study to compare 2 different GVHD prevention (prophylaxis) approaches. The researchers will see which approach is good or more effective at preventing chronic GVHD until 1 year after allogeneic hematopoietic stem cell transplantation (allo-HCT).

Timeline

Start
2026-01-20
Primary completion
2029-01
Completion
2029-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Cyclophosphamide Other / unclassified
Subject Ruxolitinib Small molecule
Subject Tacrolimus Small molecule
Background Mycophenolate Mofetil Small molecule