Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block

Phase 2 Completed 79 enrolled Hainan Medical College The Second Affiliated Hospital of Hainan Medical University · collab

NaSequentialOpen-labelHealth-services research

Summary

This prospective, sequential dose-finding clinical observational study aims to estimate the median effective concentration (EC50) and the 95% effective concentration (EC95) of liposomal bupivacaine for ultrasound-guided femoral nerve block. Sensory and motor block endpoints are evaluated separately at 30 minutes after block placement using a modified up-and-down (sequential allocation) design, with trial termination after eight reversal points.

Timeline

Start: 2026-02-01
Primary completion: 2026-03-31
Completion: 2026-04-01

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupivacaine	Other / unclassified	266 mg	—

Indications

No indication recorded.